Female-Specific Hypertension Loci on Rat Chromosome 13
Female-Specific Hypertension Loci on Rat Chromosome 13
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DOI：
10.1161/hypertensionaha.113.01708
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发表时间：
2013-09-01
期刊：
影响因子：
8.3
通讯作者：
Moreno, Carol
中科院分区：
文献类型：
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作者：
Hoffman, Matthew J.;Flister, Michael J.;Moreno, Carol
大鼠13号染色体的3.7-Mb区域（45.2-49.0 Mb）仅影响雌性的血压（BP），表明在靠近肾素位点的位置存在性别特异性BP位点。在本研究中，我们使用了一系列的达尔盐敏感/Mcwi-13布朗挪威同源大鼠品系，以进一步解决BP位点在这一地区。我们确定了3个BP位点只影响雌性大鼠，其中2个较小的位点（线9（BP 3）和线9（BP 4））的功能特征的序列和表达分析。与SS（SS/HsdMcwiCrl）相比，BN（BN/NHsdMcwi）13号染色体591-kb区域的存在（第9系（BP 3））在8%NaCl饮食下显著降低血压21 mm Hg（153 +/- 7 vs 174 +/- 5 mm Hg; P
A 3.7-Mb region of rat chromosome 13 (45.2-49.0 Mb) affects blood pressure (BP) in females only, indicating the presence of sex-specific BP loci in close proximity to the Renin locus. In the present study, we used a series of Dahl salt-sensitive/Mcwi-13 Brown Norway congenic rat strains to further resolve BP loci within this region. We identified 3 BP loci affecting female rats only, of which the 2 smaller loci (line9(BP3) and line9(BP4)) were functionally characterized by sequence and expression analysis. Compared with SS (SS/HsdMcwiCrl), the presence of a 591-kb region of BN (BN/NHsdMcwi) chromosome 13 (line9(BP3)) significantly lowered BP by 21 mm Hg on an 8% NaCl diet (153 +/- 7 versus 174 +/- 5 mm Hg; P