Tissue damage force estimation in porcine small intestine from its elasticity
Tissue damage force estimation in porcine small intestine from its elasticity
复制标题
从猪小肠的弹性评估组织损伤力
DOI：
10.1007/s11548-022-02794-x
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发表时间：
2022
影响因子：
3
通讯作者：
Sakuma Ichiro
中科院分区：
文献类型：
--
作者：
Yamamoto Kenzo;Hara Kazuaki;Kobayashi Etsuko;Akagi Yuki;Sakuma Ichiro
目的手术后并发症与手术者的技术水平有关。因此，人们正在努力寻找提高外科医生技术技能的方法，例如在手术过程中不会对组织造成不必要的损伤。在这项研究中，我们的目的是探讨估计生物组织损伤的可能性，在防止不必要的损伤在surgery. MethodsA系列的拉伸试验进行猪小肠组织，以确定弹性和撕裂力。然后，在显微镜下观察到的组织中的纤维蛋白质配置的影响，在组织的力学properties. ResultsThe从拉伸试验的结果表明，断裂能与弹性的负0.5次方（R2 = 0.897），这也建议由现有的聚合物材料的损伤模型（湖-托马斯模型）的正相关和线性相关。从微观观察的结果也表明了类似的影响纤维的配置对弹性建议在聚合物力学结论猪小肠组织的断裂能与弹性之间存在相关性，这一点在高分子力学中也得到了证实，因此是一种有希望的途径，能够估计施加到生物组织上的最大作用力，而不会在手术期间造成损伤。然而，还应注意调查聚合物力学和生物力学重叠的程度。
PurposePost-surgical complications are correlated to the surgeon’s technical skill level. Thus, efforts are being put in finding ways to improve the surgeon’s technical skills, such as not causing unwanted damage to tissues during surgery. In this study, we aim to investigate the possibility of estimating biological tissue damage, in view of preventing unwanted damage during surgery.MethodsA series of tensile tests were performed on porcine small intestinal tissue to determine the elasticity and the tearing force. The tissue was then microscopically observed to investigate the influence of fibrous protein configuration in the tissue’s mechanical properties.ResultsThe results from the tensile test showed that the fracture energy had a positive and linear correlation with the elasticity to the negative 0.5th power (R2= 0.897), which was also suggested by an existing damage model for polymeric materials (Lake-Thomas model). The results from the microscopic observations also showed a resembling influence of fiber configuration on the elasticity as suggested in polymer mechanics (affine network model).ConclusionWe showed that the fracture energy had a correlation with the elasticity in porcine small intestinal tissues, which was also suggested in polymer mechanics, thus being a promising avenue toward the ability to estimate the maximum applicable force onto a biological tissue without causing damage during surgery. Attention should also be pointed, however, towards investigating the extent at which polymer mechanics and biomechanics overlap.