Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography
Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography
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DOI：
10.1542/peds.103.6.1263
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发表时间：
1999-06-01
期刊：
影响因子：
8
通讯作者：
Azzopardi, D
中科院分区：
文献类型：
--
作者：
al Naqeeb, N;Edwards, AD;Azzopardi, D
Objective.定义正常和异常模式，测试观察者间的变异性，以及新生儿脑病发作后不久振幅整合脑电图（aEEG）的预后准确性。对新生儿脑病的连续病例（n = 56;妊娠中位数，40;范围，35-42周）和健康婴儿（n = 14;妊娠中位数，40;范围，39-40周）进行了研究。使用脑功能监测仪记录aEEG，中位数为0，范围为0-21日龄。在这些婴儿中，56名脑病婴儿中的24名和所有正常婴儿在出生后12小时内进行了研究（中位数，5;范围，3-12小时）。40名婴儿被怀疑出生时窒息。定义了正常和异常模式的标准，并确定了这些分类的观察者间变异性。结果与18至24个月龄时评估的神经发育结果进行比较，aEEG也与标准EEG和磁共振成像进行比较。对照组婴儿aEEG活动最宽频带的中位上限为37.5 μ V（范围，30-48 μ V），中位下限为8 μ V（范围，6.5-11 μ V）。我们将aEEG背景活动分为正常振幅（aEEG活动带上缘>10 μ V，下缘>5 μ V）、中度异常振幅（aEEG活动带上缘>10 μ V，下缘≤ 5 μ V）和抑制振幅（aEEG活动带上缘
Objective. To define normal and abnormal patterns, test interobserver variability, and the prognostic accuracy of amplitude-integrated electroencephalography (aEEG) soon after the onset of neonatal encephalopathy.Methods. Consecutive cases of neonatal encephalopathy (n = 56; gestation median, 40; range, 35-42 weeks) and healthy infants (n = 14; gestation median, 40; range, 39-40 weeks) were studied. aEEG was recorded using a cerebral function monitor, at median, 0, range, 0-21 days of age. Of the infants, 24 of the 56 with encephalopathy and all of the normal infants were studied within 12 hours of birth (median, 5; range, 3-12 hours). Forty infants were suspected of having suffered birth asphyxia. Criteria for normal and abnormal patterns were defined and the interobserver variability of these classifications determined. Results were compared with neurodevelopmental outcome assessed at 18 to 24 months of age, aEEG also was compared with a standard EEG and with magnetic resonance imaging.Results. The median upper margin of the widest band of aEEG activity in the control infants was 37.5 mu V (range, 30-48 mu V), and median lower margin was 8 mu V (range, 6.5-11 mu V). We classified the aEEG background activity as normal amplitude, the upper margin of band of aEEG activity >10 mu V and the lower margin >5 mu V; moderately abnormal amplitude, the upper margin of band of aEEG activity >10 mu V and the lower margin less than or equal to 5 mu V; and suppressed amplitude, the upper margin of the band of aEEG activity