An Alternative Approach to Direct Aldol Reaction Based on Gold‐Catalyzed Methoxyl Transfer
An Alternative Approach to Direct Aldol Reaction Based on Gold‐Catalyzed Methoxyl Transfer
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DOI：
10.1002/adsc.201100789
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发表时间：
2012-04
影响因子：
5.4
通讯作者：
Moran Zhang;Yunxia Wang;Yang Yang-Yang;Xiangdong Hu
中科院分区：
文献类型：
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作者：
Moran Zhang;Yunxia Wang;Yang Yang-Yang;Xiangdong Hu
基于金催化的甲氧基从二甲缩醛到末端炔烃的转移，开发了一种温和的催化替代直接Aldol反应的方法。由于缩醛的同时活化，这种Aldol方法只适用于缩醛，而不适用于醛。还观察到了金络合物的配位效应。
A mild and catalyzed alternative to the direct aldol reaction has been developed based on the gold-catalyzed methoxy group transfer from dimethyl acetals to terminal alkynes. Due to the simultaneous activation of the acetals, this aldol approach is only functional for acetals but not aldehydes. A ligand effect from the gold complex has also been observed.