COMPARISON OF THE BONE-MINERAL CONTENT OF THE LOWER-LIMBS IN MEN WITH ISCHEMIC ATHEROSCLEROTIC DISEASE
COMPARISON OF THE BONE-MINERAL CONTENT OF THE LOWER-LIMBS IN MEN WITH ISCHEMIC ATHEROSCLEROTIC DISEASE
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DOI：
10.1007/bf02243003
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发表时间：
1994-12-01
影响因子：
3.4
通讯作者：
MAZIERES, B
中科院分区：
文献类型：
--
作者：
LAROCHE, M;POUILLES, JM;MAZIERES, B
在先前的一项研究中，作者证明了17名患有缺血性动脉粥样硬化疾病的男性股骨颈的骨矿物质密度（BMD）低于匹配的对照组。动脉疾病患者比对照组更瘦，吸烟更严重。骨质疏松症和下肢动脉疾病可能是由于共同的危险因素：吸烟和低体质指数。为了证明动脉粥样硬化对骨矿物质含量（BMC）的直接影响，作者采用双能x线吸收仪研究了18例下肢动脉疾病患者的双腿BMC，并通过多普勒超声测量远端收缩指数进行量化。受动脉疾病影响更严重的腿部的平均BMC显著低于受动脉疾病影响较小的腿部的平均BMC （512 +/- 76 g对495 +/- 80 g: p = 0.003）。在18例患者中，13例下肢BMC受动脉疾病影响更严重；18例患者中有4例左右腿BMC差异小于1%，有1例患者受动脉疾病影响更大的那条腿BMC更高。下肢动脉疾病可导致骨矿物质流失。
In a previous study, the authors demonstrated that in 17 men with ischaemic atherosclerotic disease the bone mineral density (BMD) of the femoral neck was lower than in matched control subjects. The patients with arterial disease were thinner and were heavier smokers than the controls. Osteoporosis and arterial disease of the lower limbs were perhaps due to common risk factors: tobacco consumption and a low body build index. In order to demonstrate the direct effect of atherosclerosis on bone mineral content (BMC), the authors studied by dual-energy X-ray absorptiometry the BMC of both legs in 18 men presenting symptomatic arterial disease of the lower limbs quantified by measurement of distal systolic indexes by doppler ultrasonography.The mean BMC of the leg more severely affected by arterial disease was significantly lower than the mean BMC of the leg less affected by arterial disease (512 +/- 76 g versus 495 +/- 80 g: p = 0.003). In 13 of the 18 patients, the BMC was lower in the leg more severely affected by arterial disease; in 4 of 18 the difference between the BMC of the left and right legs was less than 1%, and in a single patient the BMC was higher in the leg more affected by arterial disease.Arterial disease of the lower limbs could lead to bone mineral loss.