Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids
Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids
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DOI：
10.1093/ajcn/71.1.292s
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发表时间：
2000-01-01
影响因子：
7.1
通讯作者：
Heird, WC
中科院分区：
文献类型：
--
作者：
Jensen, CL;Maude, M;Heird, WC
为了确定母乳喂养的母亲补充二十二碳六烯酸（DHA）是否会增加母乳和婴儿血浆磷脂（PP）的DHA含量，将母乳喂养的妇女随机分配到3个DHA补充组（170-260 mg/d）或对照组。第1组（n = 6）食用藻类生产的高DHA三酰甘油;第2组（n = 6）食用高DHA鸡蛋;第3组（n = 6）食用高DHA，低二十碳五烯酸海洋油;第4组（n = 6）没有接受补充剂。从补充前到补充后（产后2周和8周），组I、2和3的平均（+/-SD）母体PP DHA分别增加1.20 +/- 0.53、0.63 +/- 0.82和0.76 +/- 0.35 mol%的脂肪酸（23-41%），但在第4组中降低了0.44 +/-0.34mol%（15%）。第1、3和3组的母乳DHA分别增加0.21 +/- 0.16、0.07 +/- 0.11和0.12 +/- 0.07 mol%（32-91%），但第4组减少0.03 +/- 0.04 mol%（17%）。第1、2和3组的平均婴儿PP DHA分别增加1.63 +/- 0.79、0.40 +/- 1.0和0.98 +/- 0.61 mol%（11-42%），但第4组仅增加0.18 +/- 0.74 mol%（5%）。母亲血浆DHA含量与母乳DHA含量、母乳DHA含量与婴儿PPs含量均呈显著相关。第2组的母乳和母婴PP 22：n-6浓度最低。补充DHA可增加哺乳期妇女的血浆和母乳DHA浓度，导致婴儿的PP DHA浓度更高。
To determine whether docosahexaenoic acid (DHA) supplementation of breast-feeding mothers increases the DHA contents of breast milk and infant plasma phospholipids (PPs) breast-feeding women were randomly assigned to 3 DHA-supplementation groups(170-260 mg/d) or a control group. Group 1 (n = 6) consumed an algae-produced high-DHA triacylglycerol; group 2(n = 6) consumed high-DHA eggs; group 3 (n = 6) consumed a high-DHA, low-eicosapentaenoic acid marine oil; and group 4 (n = 6) received no supplementation. From before to after supplementation (2 and 8 wk postpartum), mean (+/-SD) maternal PP DHA increased in groups I, 2, and 3 by 1.20 +/- 0.53, 0.63 +/- 0.82, and 0.76 +/- 0.35 mol% of fatty acids, respectively (23-41%), but decreased in group 4 by 0.44 +/- 0.34 mol% (15%). Breast-milk DHA of groups 1, 3, and 3 increased by 0.21 +/- 0.16, 0.07 +/- 0.11, and 0.12 +/- 0.07 mol%, respectively (32-91%) but decreased in group 4 by 0.03 +/- 0.04 mol% (17%). Mean infant PP DHA in groups 1, 2, and 3 increased by 1.63 +/- 0.79, 0.40 +/- 1.0, and 0.98 +/- 0.61 mol%, respectively (11-42%), but only by 0.18 +/- 0.74 mol% (5%) in group 4. Correlations between the DHA contents of maternal plasma and breast milk and of milk and infant PPs were significant. Breast-milk and maternal and infant PP 22:n-6 concentrations were lowest in group 2. DHA supplementation increases the plasma and breast-milk DHA concentrations of lactating women, resulting in higher PP DHA concentrations in infants.