Effect of dietary patterns on serum homocysteine - Results of a randomized, controlled feeding study
Effect of dietary patterns on serum homocysteine - Results of a randomized, controlled feeding study
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DOI：
10.1161/01.cir.102.8.852
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发表时间：
2000-08-22
期刊：
影响因子：
37.8
通讯作者：
Selhub, J
中科院分区：
文献类型：
--
作者：
Appel, LJ;Miller, ER;Selhub, J
背景-血中同型半胱氨酸水平升高与动脉粥样硬化性心血管疾病风险增加相关。虽然许多研究已经评估了维生素补充剂对同型半胱氨酸的影响，饮食模式对同型半胱氨酸的影响还没有得到很好的studied.Methods和Results-During 3-week run-in，118名参与者被喂以控制饮食，低水果，蔬菜和乳制品，与脂肪含量典型的美国消费。在为期8周的干预阶段，参与者被随机分配3种饮食中的一种：对照饮食，富含水果和蔬菜但其他方面与对照相似的饮食，或富含水果，蔬菜和低脂乳制品并减少饱和脂肪和总脂肪的组合饮食。在导入期和干预期结束之间，对照饮食中同型半胱氨酸的平均变化为+0.46 μ mol/L，水果和蔬菜饮食中为+0.21 μ mol/L（与对照组相比P=0.47），而在组合饲料中为-0.34 μ mol/L（与对照组相比P=0.03，与水果和蔬菜饮食相比P=0.12），在多变量回归模型中，同型半胱氨酸的变化与血清叶酸的变化呈显著负相关（P=0.03），但与血清维生素B-12的变化无关（P=0.64）或吡哆醛5'磷酸，辅酶形式的维生素B-6（P=0.83）。结论：饮食结构的改变对血清总同型半胱氨酸的空腹水平有显著影响。这些结果为饮食可能影响动脉粥样硬化性心血管疾病发生的机制提供了额外的见解。
Background-Elevated blood levels of homocysteine are associated with an increased risk of atherosclerotic cardiovascular disease. Although numerous studies have assessed the impact of vitamin supplements on homocysteine, the effect of dietary patterns on homocysteine has not been well studied.Methods and Results-During a 3-week run-in, 118 participants were fed a control diet, low in fruits, vegetables, and dairy products, with a fat content typical of US consumption. During an 8-week intervention phase, participants were then fed 1 of 3 randomly assigned diets: the control diet, a diet rich in fruits and vegetables but otherwise similar to control, or a combination diet rich in fruits, vegetables, and low-fat dairy products and reduced in saturated and total fat. Between the end of run-in and intervention periods, mean change in homocysteine was +0.46 mu mol/L in the control diet, +0.21 mu mol/L in the fruits and vegetables diet (P=0.47 compared with control), and -0.34 mu mol/L in the combination diet (P=0.03 compared with control, P=0.12 compared with the fruits and vegetables diet), In multivariable regression models, change in homocysteine was significantly and inversely associated with change in serum folate (P=0.03) but not with change in serum vitamin B-12 (P=0.64) or pyridoxal 5' phosphate, the coenzyme form of vitamin B-6 (P=0.83).Conclusions-Modification of dietary patterns can have substantial effects on fasting levels of total serum homocysteine. These results provide additional insights into the mechanisms by which diet might influence the occurrence of atherosclerotic cardiovascular disease.