Complementary pathways in mammalian female sex determination.
Complementary pathways in mammalian female sex determination.
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DOI：
10.1186/jbiol173
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发表时间：
2009-09-02
影响因子：
--
通讯作者：
Vassalli JD
中科院分区：
文献类型：
--
作者：
Nef S;Vassalli JD
在哺乳动物中，胚胎的性别由性腺的命运决定。最近的论文，包括BMC Developmental Biology上的一篇，阐明了卵巢发育的分子调控，并表明R-spondin 1/Wnt 4/β-catenin途径和Foxl 2转录因子以互补的方式促进卵巢命运并抑制睾丸发育。
In mammals, the sex of the embryo is determined by the fate of the gonad. Recent papers, including one in BMC Developmental Biology, shed light on the molecular regulation of ovarian development and suggest that the R-spondin1/Wnt4/β-catenin pathway and the Foxl2 transcription factor act in a complementary manner to promote ovarian fate and to repress testicular development.