Cellular factors implicated in filovirus entry.
Cellular factors implicated in filovirus entry.
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DOI：
10.1155/2013/487585
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发表时间：
2013
影响因子：
2.2
通讯作者：
Hope TJ
中科院分区：
文献类型：
--
作者：
Bhattacharyya S;Hope TJ
虽然丝状病毒感染仍在世界不同地区发生，但目前还没有有效的预防或治疗策略。丝状病毒不仅会导致致命的感染，而且还有可能被用作生物武器。因此，必须全面研究这些病毒，以制定有效的战略，以防止这些感染的发生。进入是丝状病毒复制周期中的最重要步骤，并且不同的研究已经报道了在该过程中涉及无数细胞因子，包括质膜组分、细胞骨架蛋白、内体组分和胞质因子。信号传导分子如TAM家族的受体酪氨酸激酶，包括Tyro 3、Axl和Mer，也被认为是推定的进入因子。此外，丝状病毒被认为与共同受体结合，最近的研究提出T细胞免疫球蛋白和粘蛋白结构域1（TIM-1）和尼曼-皮克C1（NPC 1）作为潜在的受体候选物。本文总结了丝状病毒进入的现有文献，特别关注参与这一过程的细胞因子，并强调了一些基本问题。未来旨在回答这些问题的研究可能在设计新的抗病毒治疗方法方面非常有用。
Although filoviral infections are still occurring in different parts of the world, there are no effective preventive or treatment strategies currently available against them. Not only do filoviruses cause a deadly infection, but they also have the potential of being used as biological weapons. This makes it imperative to comprehensively study these viruses in order to devise effective strategies to prevent the occurrence of these infections. Entry is the foremost step in the filoviral replication cycle and different studies have reported the involvement of a myriad of cellular factors including plasma membrane components, cytoskeletal proteins, endosomal components, and cytosolic factors in this process. Signaling molecules such as the TAM family of receptor tyrosine kinases comprising of Tyro3, Axl, and Mer have also been implicated as putative entry factors. Additionally, filoviruses are suggested to bind to a common receptor and recent studies have proposed T-cell immunoglobulin and mucin domain 1 (TIM-1) and Niemann-Pick C1 (NPC1) as potential receptor candidates. This paper summarizes the existing literature on filoviral entry with a special focus on cellular factors involved in this process and also highlights some fundamental questions. Future research aimed at answering these questions could be very useful in designing novel antiviral therapeutics.