Spectrum of interstitial lung diseases at a tertiary center in a developing country: A study of 803 subjects.
Spectrum of interstitial lung diseases at a tertiary center in a developing country: A study of 803 subjects.
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DOI：
10.1371/journal.pone.0191938
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Behera D
中科院分区：
文献类型：
--
作者：
Dhooria S;Agarwal R;Sehgal IS;Prasad KT;Garg M;Bal A;Aggarwal AN;Behera D
间质性肺病(ILDS)的谱主要来自发达国家；来自发展中国家的数据稀少且相互矛盾。这项研究的目的是描述发展中国家的各种ILDs的分布情况。这是一个前瞻性收集的临床，放射学和组织学数据的分析，连续的受试者(年龄和12岁)来自单一的三级护理医疗中心。根据各种ILDS的标准诊断ILD的特定亚型。2015年3月至2017年2月共登记了803名受试者(平均年龄50.6岁；50.2%为女性)，其中566人(70.5%)是在研究期间诊断的(事件病例)。结节病(42.2%)、特发性肺纤维化(21.2%)、结缔组织病(CTD)相关性ILDS(12.7%)、过敏性肺炎(10.7%)和非IPF特发性间质性肺炎(9.2%)是最常见的ILDS。发病病例和流行病例的ILDS谱无显著差异(p=0.87)。49.9%的受试者获得了组织病理学标本，40.6%的受试者获得了组织学确诊。402名患者没有进行诊断程序；最常见的原因是在高分辨率CT上存在明确的常见间质性肺炎模式，以及患者不愿接受该程序。结节病、IPF和CTD-ILDS是印度北部三级中心最常见的ILDS，与发达国家报告的谱型相似。发展中国家需要进行更多的研究，以确定不同地理位置的ILDS的范围。
The spectrum of interstitial lung diseases (ILDs) have mainly been reported from the developed countries; data from developing countries is sparse and conflicting. The aim of this study is to describe the distribution of various ILDs from a developing country. This is an analysis of prospectively collected clinical, radiological and histological data of consecutive subjects (age >12 years) with ILDs from a single tertiary care medical center. The diagnosis of the specific subtype of ILD was made according to standard criteria for various ILDs. A total of 803 subjects (mean age, 50.6 years; 50.2% women) were enrolled between March 2015 to February 2017 of which 566 (70.5%) were diagnosed during the study period (incident cases). Sarcoidosis (42.2%), idiopathic pulmonary fibrosis (IPF, 21.2%), connective tissue disease (CTD)-related ILDs (12.7%), hypersensitivity pneumonitis (10.7%), and non-IPF idiopathic interstitial pneumonias (9.2%) were the most common ILDs. The spectrum of ILDs was not significantly different (p = 0.87) between incident and prevalent cases. A histopathological specimen was obtained in 49.9% of the subjects yielding a histologically confirmed diagnosis in 40.6%. A diagnostic procedure was not performed in 402 subjects; the most common reasons were presence of definite usual interstitial pneumonia pattern on high resolution computed tomography and patients’ unwillingness to undergo the procedure. Sarcoidosis, IPF and CTD-ILDs were the most common ILDs seen at a tertiary center in northern India similar to the spectrum reported from developed countries. More studies are required from developing countries to ascertain the spectrum of ILDs in different geographic locales.
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DOI：
10.1016/j.jtcvs.2014.01.028
发表时间：
2014-08-01
影响因子：
6
作者：
Dhooria, Sahajal;Agarwal, Ritesh;Gupta, Dheeraj
通讯作者：
Gupta, Dheeraj
DOI：
10.4103/0970-2113.177463
发表时间：
2016-03
期刊：
Lung India : official organ of Indian Chest Society
影响因子：
--
作者：
Dhooria S;Sehgal IS;Bal A;Aggarwal AN;Behera D;Agarwal R
通讯作者：
Agarwal R
DOI：
10.1164/rccm.2009-040gl
发表时间：
2011-03-15
影响因子：
24.7
作者：
Raghu, Ganesh;Collard, Harold R.;Schuenemann, Holger J.
通讯作者：
Schuenemann, Holger J.
影响因子：
1.7
作者：
Musellim, Benan;Okumus, Gulfer;Calisir, Haluk Celalettin
通讯作者：
Calisir, Haluk Celalettin
影响因子：
24.3
作者：
Fischer, Aryeh;Antoniou, Katerina M.;Cottin, Vincent
通讯作者：
Cottin, Vincent