Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems
Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems
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DOI：
10.1039/b701744h
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发表时间：
2007-01-01
影响因子：
4.9
通讯作者：
Lin, Victor S. -Y.
中科院分区：
文献类型：
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作者：
Trewyn, Brian G.;Giri, Supratim;Lin, Victor S. -Y.
在控制具有高表面积（>700 m2 g-1）和孔体积（>1 cm 3 g-1）的结构限定的中孔二氧化硅材料的表面性质和颗粒形态方面的最新进展显著增强了它们的生物相容性。已经开发了各种方法用于这些硅酸盐的内部孔和外部颗粒表面的官能化，这些硅酸盐具有范围从2至30 nm的可调孔径和窄的孔径分布。本文综述了近年来用于药物、基因等化学物质刺激响应性控释的功能性介孔二氧化硅材料的研究进展。最后，综述了近年来利用纳米多孔材料作为传感器对多种神经递质和生物分子进行选择性检测的研究进展。
Recent advancements in controlling the surface properties and particle morphology of the structurally defined mesoporous silica materials with high surface area (>700 m2 g−1) and pore volume (>1 cm3 g−1) have significantly enhanced their biocompatibility. Various methods have been developed for the functionalization of both the internal pore and exterior particle surfaces of these silicates with a tunable pore diameter ranging from 2 to 30 nm and a narrow pore size distribution. Herein, we review the recent research progress on the design of functional mesoporous silica materials for stimuli-responsive controlled release delivery of pharmaceutical drugs, genes, and other chemicals. Furthermore, the recent breakthroughs in utilizing these nanoscale porous materials as sensors for selective detections of various neurotransmitters and biological molecules are summarized.