Subarachnoid Midazolam: Histologic Study in Rats and Report of Its Effect on Chronic Pain in Humans
Subarachnoid Midazolam: Histologic Study in Rats and Report of Its Effect on Chronic Pain in Humans
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蛛网膜下腔咪达唑仑：大鼠组织学研究及其对人类慢性疼痛影响的报告
DOI：
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发表时间：
1991
影响因子：
5.1
通讯作者：
J. Bazin
中科院分区：
文献类型：
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作者：
P. Schoeffler;J. Taxi;P. Auroy;A. Woda;J. Bazin
蛛网膜下腔注射水溶性苯二氮卓类药物咪达唑仑用于控制癌症疼痛。首先，在大鼠蛛网膜下腔持续给药(每天50μg)期间，评估了其毒性。治疗15天后，脊髓组织学检查显示，对照组(n=14)仅接受生理盐水治疗，与蛛网膜下腔注射咪达唑仑(n=18)的对照组(n=18)脊髓组织学检查显示相同数量的纤维化、浸润和变形。因此，脊髓中观察到的组织学变化可能与导管的存在有关。在这些结果之后，两名对大剂量吗啡耐受的慢性肿瘤性疼痛的患者注射了2毫克咪达唑仑和不同剂量的蛛网膜下腔吗啡的混合物。在这两个病例中，添加咪达唑仑似乎在控制顽固性肿瘤疼痛方面有效。
Subarachnoid administration via a catheter of a water-soluble benzodiazepine, midazolam, was tested in the control of cancer pain. First, the lack of its toxicity during constant subarachnoid administration (50 μg per day) was assessed in the rat. After 15 days of treatment, a histologic examination of the spinal cord revealed the same amount of fibrosis, infiltration, and deformation in the control group ( n = 14), which had received only saline, as in the test group ( n = 18), treated with subarachnoid midazolam. Therefore, the histologic changes observed in the spinal cord probably are related to the presence of the catheter. After these results, a mixture of 2 mg midazolam and a variable dose of subarachnoid morphine was injected in two patients presenting chronic neoplastic pain resistant to high doses of morphine. In these two cases, the addition of midazolam appeared to be effective in controlling intractable neoplastic pain.