Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease
Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease
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DOI：
10.1056/nejmoa030535
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发表时间：
2003-10-23
影响因子：
158.5
通讯作者：
Lackner, KJ
中科院分区：
文献类型：
--
作者：
Blankenberg, S;Rupprecht, HJ;Lackner, KJ
背景：细胞抗氧化酶如谷胱甘肽过氧化物酶1和超氧化物歧化酶在控制氧自由基中起着核心作用。体外数据和动物模型研究表明，这些酶可以预防动脉粥样硬化，但对它们与人类疾病的相关性知之甚少。方法：我们在636名疑似冠心病患者中进行了一项前瞻性研究，中位随访期为4.7年(最长为5.4年)，以评估与基线红细胞谷胱甘肽过氧化物酶1和超氧化物歧化酶活性相关的心血管事件的风险。结果：谷胱甘肽过氧化物酶1活性是心血管事件风险的最强单变量预测因子之一，而超氧化物歧化酶活性与风险无关。心血管事件的风险与谷胱甘肽过氧化物酶1活性增加四分位数呈负相关(P
BACKGROUND:Cellular antioxidant enzymes such as glutathione peroxidase 1 and superoxide dismutase have a central role in the control of reactive oxygen species. In vitro data and studies in animal models suggest that these enzymes may protect against atherosclerosis, but little is known about their relevance to human disease.METHODS:We conducted a prospective study among 636 patients with suspected coronary artery disease, with a median follow-up period of 4.7 years (maximum, 5.4) to assess the risk of cardiovascular events associated with base-line erythrocyte glutathione peroxidase 1 and superoxide dismutase activity.RESULTS:Glutathione peroxidase 1 activity was among the strongest univariate predictors of the risk of cardiovascular events, whereas superoxide dismutase activity had no association with risk. The risk of cardiovascular events was inversely associated with increasing quartiles of glutathione peroxidase 1 activity (P for trend