EIMERIA-TENELLA IN CHICKENS - STUDIES ON RESISTANCE TO ANTICOCCIDIAL DRUGS MONENSIN AND LASALOCID
EIMERIA-TENELLA IN CHICKENS - STUDIES ON RESISTANCE TO ANTICOCCIDIAL DRUGS MONENSIN AND LASALOCID
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DOI：
10.1016/0304-4017(76)90074-1
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发表时间：
1976-01-01
影响因子：
2.6
通讯作者：
CHAPMAN, HD
中科院分区：
文献类型：
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作者：
CHAPMAN, HD
描述了柔嫩艾美耳球虫Houghton株对莫能菌素和拉沙洛西德的反应。两种药物都不能在125ppm完全控制这种菌株。在这个浓度下，莫能菌素不能完全抑制给予10个卵囊的禽类的卵囊产生。在较高浓度下，两种药物均能控制禽类中的柔嫩艾美耳球虫，给药1倍。105个卵囊，但莫能菌素有毒性。莫能菌素(375ppm)不能阻止给药4次的禽类卵囊的产生。106个卵囊。在药物存在下连续传代12代后，不能对这两种化合物中的任何一种产生耐药性。柔嫩艾美耳球虫(H)在莫能菌素存在下连续传代，致病性增加。这种更强的致病性并不是因为在宿主中有更好的繁殖能力。
The response of the Houghton strain of E. tenella to monensin and lasalocid is described. Neither drug was able to completely control this strain at 125 ppm. At this concentration oocyst production was not completely suppressed by monensin in birds given 10 oocysts. At higher concentrations both drugs were able to control E. tenella (H) in birds given 1 .times. 105 oocysts but monensin was toxic. Monensin (375 ppm) did not prevent oocyst production in birds given 4 .times. 106 oocysts. Resistance could not be developed to either of these compounds after 12 serial passages in the presence of drug. Serial passage of E. tenella (H) in the presence of monensin resulted in an increase in pathogenicity. This greater pathogenicity was not due to a better ability to multiply in the host.