IMMUNOCHEMICAL STUDIES ON PROTEIN PATHOLOGY - THE IMMUNOGLOBULIN CONCEPT
IMMUNOCHEMICAL STUDIES ON PROTEIN PATHOLOGY - THE IMMUNOGLOBULIN CONCEPT
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DOI：
10.1016/0009-8981(59)90004-x
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发表时间：
1959-01-01
影响因子：
5
通讯作者：
HEREMANS, JF
中科院分区：
文献类型：
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作者：
HEREMANS, JF
本研究选择了三种血清蛋白，因为它们具有密切的化学、免疫学和功能关系。它们是γ-球蛋白，β 2a -球蛋白和β2-巨球蛋白。它们似乎是抗体活性的载体，我们建议称它们为免疫球蛋白。在慢性感染、胶原蛋白疾病和肝硬化（以及肝炎）中，血清中这三种免疫球蛋白明显增加。这可能与抗体合成有关。与免疫麻痹相关的疾病（原发性和继发性无球蛋白血症和生物学相关综合征）的特征是三种免疫球蛋白中的至少一种下降。来源于网状内皮系统的细胞类型（骨髓瘤、巨球蛋白血症、网状肉瘤、白血病）增殖不受控制的疾病可能产生“副蛋白”，它总是一种（有时是两种）免疫球蛋白的衍生物。似乎有一个规律，在这种情况下，那些不参与副蛋白血症的免疫球蛋白的产生明显减少。
Three serum proteins have been selected for this study because of their close chemical, immunological and functional relationships. These are γ-globulin,β2A-globulin andβ2-macroglobulin.They appear to be the carriers of antibody activity and we propose to call them by the name ofimmunoglobulins.In chronic infections, collagen diseases and cirrhosis (as well as hepatitis) all three immunoglobulins increase markedly in serum. This may be correlated to antibody synthesis.Diseases associated with immune paralysis (primary and secondary agammaglob-ulinemia and biologically related syndromes) are characterized by the fall of at least one of the three immunoglobulins.Diseases with uncontrolled proliferation of cell types derived from the reticuloendothelial system (myeloma, macroglobulinemia, reticulo-sarcoma, leukemias) may give rise to “paraproteins”, which invariably appear to be derivatives of one (sometimes two) of the immunoglobulins. There seems to be a rule that in such cases the production of those of the immunoglobulins which take no part in the paraproteinemia is markedly reduced.