Critical periods for functional and anatomical compensation in lateral suprasylvian visual area following removal of visual cortex in cats.
Critical periods for functional and anatomical compensation in lateral suprasylvian visual area following removal of visual cortex in cats.
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猫视觉皮层切除后侧外侧视觉区域功能和解剖补偿的关键期。
DOI：
10.1152/jn.1984.52.5.941
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发表时间：
1984
影响因子：
2.5
通讯作者：
Spear,PD
中科院分区：
文献类型：
--
作者：
Tong,L;Kalil,RE;Spear,PD
先前的实验已经发现，在猫的外侧上裂（LS）视觉皮质区的神经元显示功能补偿后，视觉皮质区17，18和19在出生当天删除。相应地，增强的视网膜-丘脑途径LS皮质发展在这些猫。本实验研究了这些变化的临界期。在出生后1天至26周的猫中进行了17、18和19区的单侧病变。当猫是成年人，单细胞记录从LS皮质同侧的病变。此外，transneuronal放射自显影方法被用来跟踪的视网膜-丘脑投射到LS皮质在许多相同的动物。在18和26周龄的猫病变后，方向选择性LS皮质细胞明显减少，对静止闪光刺激反应最好的细胞增加。这些结果与成年猫视皮层损伤后的结果相似。相反，具有这些特性的细胞的百分比在1天至12周龄的损伤后是正常的。因此，发展的方向选择性和更大的反应，移动比静止的闪光刺激在LS皮层的视觉皮层损伤后的关键时期结束之间的12和18周龄。在26周龄猫的病变后，对同侧眼睛有反应的细胞百分比降低，这与成年猫视觉皮层病变后的结果相似。然而，眼优势是正常的损害后，从1天到18周龄。因此，病变后对同侧眼反应发展的关键期在18至26周龄之间结束。在2、4或8周龄猫的视皮层病变后，约30%的LS皮层细胞显示出对细长光缝的方向选择性。相比之下，在正常成年猫、出生当天就有病变的猫或在12周龄或更晚时有病变的猫中，很少或没有细胞显示出这种特性。因此，许多LS细胞会出现异常特性，并且该特性的关键期比其他特性的关键期开始得晚（1天至2周之间），结束得早（8至12周之间）。（400字处截断摘要）
Previous experiments have found that neurons in the cat's lateral suprasylvian (LS) visual area of cortex show functional compensation following removal of visual cortical areas 17, 18, and 19 on the day of birth. Correspondingly, an enhanced retino-thalamic pathway to LS cortex develops in these cats. The present experiments investigated the critical periods for these changes. Unilateral lesions of areas 17, 18, and 19 were made in cats ranging in age from 1 day postnatal to 26 wk. When the cats were adult, single-cell recordings were made from LS cortex ipsilateral to the lesion. In addition, transneuronal autoradiographic methods were used to trace the retino-thalamic projections to LS cortex in many of the same animals. Following lesions in 18- and 26-wk-old cats, there is a marked reduction in direction-selective LS cortex cells and an increase in cells that respond best to stationary flashing stimuli. These results are similar to those following visual cortex lesions in adult cats. In contrast, the percentages of cells with these properties are normal following lesions made from 1 day to 12 wk of age. Thus the critical period for development of direction selectivity and greater responses to moving than to stationary flashing stimuli in LS cortex following a visual cortex lesion ends between 12 and 18 wk of age. Following lesions in 26-wk-old cats, there is a decrease in the percentage of cells that respond to the ipsilateral eye, which is similar to results following visual cortex lesions in adult cats. However, ocular dominance is normal following lesions made from 1 day to 18 wk of age. Thus the critical period for development of responses to the ipsilateral eye following a lesion ends between 18 and 26 wk of age. Following visual cortex lesions in 2-, 4-, or 8-wk-old cats, about 30% of the LS cortex cells display orientation selectivity to elongated slits of light. In contrast, few or no cells display this property in normal adult cats, cats with lesions made on the day of birth, or cats with lesions made at 12 wk of age or later. Thus an anomalous property develops for many LS cells, and the critical period for this property begins later (between 1 day and 2 wk) and ends earlier (between 8 and 12 wk) than those for other properties.(ABSTRACT TRUNCATED AT 400 WORDS)