RADIATION-INDUCED APOPTOSIS - RELEVANCE TO RADIOTHERAPY
RADIATION-INDUCED APOPTOSIS - RELEVANCE TO RADIOTHERAPY
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DOI：
10.1016/0360-3016(95)00214-8
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发表时间：
1995-11-01
影响因子：
7
通讯作者：
MEYN, RE
中科院分区：
文献类型：
--
作者：
DEWEY, WC;LING, CC;MEYN, RE
辐射诱导的细胞凋亡的审查方面：（a）凋亡和坏死细胞的鉴定，（B）辐射诱导的凋亡的体外和体内观察，（c）控制凋亡的基因，（d）靶点可能是质膜或核DNA的证据，（e）凋亡性死亡和生殖毒性的定量比较，（f）细胞凋亡和生殖毒性的定量比较。（克隆性）死亡，（f）放射疗法中放射诱导的细胞凋亡的重要性，和（g）需要的放射诱导的细胞凋亡的研究，应高度优先确定在放射诱导的细胞凋亡的表达和调节中重要的分子途径，具体地，在细胞可以分裂之前的间期中发生的调节细胞凋亡的事件应当与分裂之前调节DNA损伤的错误修复的事件区分开，所述错误修复导致在有丝分裂细胞中观察到的染色体畸变，其继而导致具有畸变的分裂细胞的后代通过细胞凋亡或坏死而死亡。需要鉴定决定细胞分裂时是否有染色体畸变产生的后代是坏死的还是坏死的分子事件。这些考虑对于确定辐射诱导的细胞凋亡的调节如何影响最终的克隆形成存活是重要的，以及存活后代基因组的不稳定性。
Radiation-induced apoptosis is reviewed in terms of: (a) the identification of apoptotic and necrotic cells, (b) observations in vitro and in vivo of radiation-induced apoptosis, (c) genes controlling apoptosis, (d) evidence that the target may be the plasma membrane or nuclear DNA, (e) quantitative comparisons of apoptotic death and reproductive (clonogenic) death, (f) the importance of radiation-induced apoptosis in radiotherapy, and (g) studies of radiation-induced apoptosis that are needed, High priority should be placed on determining the molecular pathways that are important in the expression and modulation of radiation-induced apoptosis, Specifically, the events that modulate the apoptosis that occurs in interphase before the cell can divide should be distinguished from the events before division that modulate the misrepair of DNA damage, that results in chromosomal aberrations observed in mitotic cells, which in turn cause the progeny of the dividing cell with aberrations to die by either apoptosis or necrosis, Then, molecular events that determine whether a cell that divides with or without a chromosomal aberration will produce progeny that apoptose or necrose need to be identified, These considerations are important for determining how medulation of radiation-induced apoptosis will affect the ultimate clonogenic survival, and possibly genomic instability in the surviving progeny.