Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells.
Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells.
复制标题
雌二醇和乙炔雌二醇对中国仓鼠V79细胞微管分布的影响。
DOI：
10.1248/cpb.40.182
复制
发表时间：
1992
影响因子：
1.7
通讯作者：
K. Ichinoseki
中科院分区：
文献类型：
--
作者：
Y. Sato;Y. Sakakibara;T. Oda;E. Aizu;K. Ichinoseki
采用荧光抗微管蛋白抗体研究了雌二醇（E2）和乙炔雌二醇（EE2）对中国仓鼠V79细胞染色体数目和细胞微管结构的影响。20 μ m E2处理48 h，仅诱导少量四倍体细胞，但正常的微管网络仅在处理3 h时就被完全破坏。这些数据表明E2在V79细胞中具有比己烯雌酚更高的微管破坏活性。
The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 microM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.