Hippocampal head atrophy after traumatic brain injury
Hippocampal head atrophy after traumatic brain injury
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DOI：
10.1016/j.neuropsychologia.2005.11.007
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Sahuquillo, Juan
中科院分区：
文献类型：
--
作者：
Ariza, Mar;Serra-Grabulosa, Josep M.;Sahuquillo, Juan
创伤性脑损伤（TBI）会导致海马损伤。海马体可以从宏观上分为头部、体部和尾部，它们对兴奋性的敏感性以及皮质连接方面有所不同。我们调查了损伤是否也根据海马区的参与而变化，并研究了海马减少与记忆性能的关系。对20名TBI患者和匹配的对照进行了检查。分别对海马头部、体部和尾部进行MRI测量。记忆结果通过Rey的听觉语言学习测试，Rey的复杂图形测试和Warrington面部识别记忆测试的修改版本进行测量。组间比较显示患者双侧海马萎缩，主要累及海马头部。此外，TBI受试者表现出言语记忆缺陷，这与左侧海马头部萎缩略有相关性。(c)2005爱思唯尔有限公司保留所有权利。
Traumatic brain injury (TBI) causes hippocampal damage. The hippocampus can be macroscopically divided into the head, body and tail, which differ in terms of their sensitivity to excitability and also in terms of their cortical connections. We investigated whether damage also varies according to the hippocampal area involved, and studied the relationship of hippocampal reductions with memory performance. Twenty TBI patients and matched controls were examined. MRI measurements were performed separately for the hippocampal head, body and tail. Memory outcome was measured by Rey's auditory verbal learning test, Rey's complex figure test and a modified version of Warrington's facial recognition memory test. Group comparison showed that patients had bilateral hippocampal atrophy, mainly involving the hippocampal head. Moreover, TBI subjects showed verbal memory deficits which presented slight correlations with left hippocampal head atrophy. (c) 2005 Elsevier Ltd. All rights reserved.