Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging.
Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging.
复制标题
DOI：
10.18632/oncotarget.12572
复制
发表时间：
2017-01-24
期刊：
影响因子：
--
通讯作者：
Su DM
中科院分区：
文献类型：
--
作者：
Coder B;Wang W;Wang L;Wu Z;Zhuge Q;Su DM
T细胞和中枢神经系统（CNS）在稳态和损伤中的相互作用已被认为是致病性的（CD 4 + T辅助细胞1 -Th 1、Th 17和γδT）和改善性的（Th 2和调节性T细胞-Th 2）。然而，旨在阐明老年微环境中的确切作用和TdR的二分作用的深入研究才刚刚开始，许多方面仍不清楚。这不仅是由于神经和T细胞免疫系统之间的相互依赖性和相互因果关系的变化和疾病，而且还由于两个系统的不一致的老化，其动态地随着CNS损伤/恢复和/或老化过程而变化。细胞免疫系统老化，特别是由胸腺退化引发的免疫衰老和T细胞老化-老年人慢性炎症（称为炎症）的来源，可能会加速大脑老化和记忆丧失。反过来，大脑的老化通过神经-内分泌-免疫网络驱动全身系统老化，包括免疫系统的老化。因此，包括疫苗接种和“保护性自身免疫”在内的免疫治疗提供了有希望的手段来恢复神经炎性疾病和修复CNS急性损伤和慢性神经变性。我们回顾了目前的理解和最近的发现，将衰老的免疫系统与中枢神经系统损伤和神经退行性变联系起来。此外，我们还讨论了潜在的恢复和复兴策略，重点是通过“胸腺炎症神经变性轴”靶向衰老T细胞免疫系统，以减轻衰老过程中的急性脑损伤和慢性神经变性。
The interaction between T cells and the central nervous system (CNS) in homeostasis and injury has been recognized being both pathogenic (CD4+ T-helper 1 - Th1, Th17 and γδT) and ameliorative (Th2 and regulatory T cells - Tregs). However, in-depth studies aimed to elucidate the precise in the aged microenvironment and the dichotomous role of Tregs have just begun and many aspects remain unclear. This is due, not only to a mutual dependency and reciprocal causation of alterations and diseases between the nervous and T cell immune systems, but also to an inconsistent aging of the two systems, which dynamically changes with CNS injury/recovery and/or aging process. Cellular immune system aging, particularly immunosenescence and T cell aging initiated by thymic involution - sources of chronic inflammation in the elderly (termed inflammaging), potentially induces an acceleration of brain aging and memory loss. In turn, aging of the brain via neuro-endocrine-immune network drives total body systemic aging, including that of the immune system. Therefore, immunotherapeutics including vaccination and “protective autoimmunity” provide promising means to rejuvenate neuro-inflammatory disorders and repair CNS acute injury and chronic neuro-degeneration. We review the current understanding and recent discoveries linking the aging immune system with CNS injury and neuro-degeneration. Additionally, we discuss potential recovery and rejuvenation strategies, focusing on targeting the aging T cell immune system in an effort to alleviate acute brain injury and chronic neuro-degeneration during aging, via the “thymus-inflammaging-neurodegeneration axis”.