Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET
Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET
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DOI：
10.1109/42.870260
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发表时间：
2000-05-01
影响因子：
10.6
通讯作者：
Cherry, SR
中科院分区：
文献类型：
--
作者：
Chatziioannou, A;Qi, J;Cherry, SR
我们已经评估了两个三维（3-D）重建算法的性能与microPET，一个高分辨率断层专用于小动物成像采集的数据。第一种是线性滤波反投影算法（FBP）与缺失数据的重投影，第二种是统计最大后验概率算法（MAP），这两种算法的分辨率性能进行了评估，无论是在幻影和在体内。获得了60个独立实现的模拟猴宝宝大脑的幻象，每个包含300万个计数。这些实现中的每一个都用这两种算法独立地重建。使用60个重建实现的集合来估计标准偏差作为每个重建算法的噪声的度量。在MAP重建中恢复了更多细节，而相对于FBP没有噪声增加。在一个简单的圆柱形隔室体模的研究表明，MAP的已知活动比的恢复。最后，体内研究也证明了使用MAP算法的空间分辨率的明显改善。MAP重建的定量准确性也通过与放射自显影术和组织样本的直接孔计数的比较进行了评价，并且显示为上级。
We have evaluated the performance of two three-dimensional (3-D) reconstruction algorithms with data acquired from microPET, a high resolution tomograph dedicated to small animal imaging. The first was a linear filtered-backprojection algorithm (FBP) with reprojection of the missing data, and the second was a statistical maximum a posteriori probability algorithm (MAP), The two algorithms were evaluated in terms of their resolution performance, both in phantoms and in vivo. Sixty independent realizations of a phantom simulating the brain of a baby monkey were acquired, each containing three million counts. Each of these realizations was reconstructed independently with both algorithms. The ensemble of the 60 reconstructed realizations was used to estimate the standard deviation as a measure of the noise for each reconstruction algorithm, More detail was recovered in the MAP reconstruction without an increase in noise relative to FBP. Studies in a simple cylindrical compartment phantom demonstrated improved recovery of known activity ratios with MAP. Finally, in vivo studies also demonstrated a clear improvement in spatial resolution using the MAP algorithm. The quantitative accuracy of the MAP reconstruction was also evaluated by comparison with autoradiography and direct well counting of tissue samples and was shown to be superior.