The Strong Influence of Structure Polymorphism on the Conductivity of Peptide Fibrils
The Strong Influence of Structure Polymorphism on the Conductivity of Peptide Fibrils
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DOI：
10.1002/anie.201604833
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发表时间：
2016-08-16
影响因子：
16.6
通讯作者：
Ashkenasy, Nurit
中科院分区：
文献类型：
--
作者：
Ivnitski, Denis;Amit, Moran;Ashkenasy, Nurit
肽原纤维纳米结构已被提倡作为未来生物技术和纳米技术装置的组成部分。然而，利用原纤维功能性用于诸如催化或电子转移的应用的能力取决于明确定义的架构的形成。描述了由被芳族基团取代的肽制成的原纤维，其呈现有效的电子离域。肽在不同条件下的自组装产生了具有明显不同电导率的多态性原纤维产物。这个过程是由氢键，静电和p-堆叠相互作用的集合驱动的，因此，它可以通过使用介质来增强特定的相互作用而不是其他相互作用来形成不同的多晶型物。该方法有助于详细表征不同的多晶型物，并允许建立特定的条件，从而产生具有最高电导率的多晶型物。
Peptide fibril nanostructures have been advocated as components of future biotechnology and nanotechnology devices. However, the ability to exploit the fibril functionality for applications, such as catalysis or electron transfer, depends on the formation of well-defined architectures. Fibrils made of peptides substituted with aromatic groups are described presenting efficient electron delocalization. Peptide self-assembly under various conditions produced polymorphic fibril products presenting distinctly different conductivities. This process is driven by a collective set of hydrogen bonding, electrostatic, and p-stacking interactions, and as a result it can be directed towards formation of a distinct polymorph by using the medium to enhance specific interactions rather than the others. This method facilitates the detailed characterization of different polymorphs, and allows specific conditions to be established that lead to the polymorph with the highest conductivity.