EFFECTS OF SEQUENCE VARIATIONS IN INNATE IMMUNE RESPONSE GENES ON INFECTIOUS OUTCOME IN TRAUMA PATIENTS: A COMPREHENSIVE REVIEW
EFFECTS OF SEQUENCE VARIATIONS IN INNATE IMMUNE RESPONSE GENES ON INFECTIOUS OUTCOME IN TRAUMA PATIENTS: A COMPREHENSIVE REVIEW
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DOI：
10.1097/shk.0000000000000450
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发表时间：
2015-11-01
期刊：
影响因子：
3.1
通讯作者：
Van Lieshout, Esther M. M.
中科院分区：
文献类型：
--
作者：
Bronkhorst, Maarten W. G. A.;Patka, Peter;Van Lieshout, Esther M. M.
感染性并发症、败血症和多器官功能障碍综合征（MODS）仍然是最初创伤后存活患者发病率和死亡率的重要原因。越来越多的证据表明，遗传变异，特别是单核苷酸多态性（SNP），是脓毒症患者炎症反应和临床结局个体间差异的关键决定因素。尽管SNP对脓毒症和MODS的影响已在许多人群和疾病中进行了研究，但本文旨在总结SNP对创伤患者感染并发症的影响的现有知识。对PubMed数据库中的可用文献进行了综述。在创伤患者群体中研究了以下基因：CD14、HMGB1、IFNG、IL1A、IL1B、IL1RN、IL4、IL6、IL8、IL10、IL17F、IL18、MBL2、MASP2、FCN 2、TLR1、TLR2、TLR4、TLR9、TNF、LTA、GR、MYLK、NLRP 3、PRDX6、HSPA1B、HSPA1L、HSP90、SERPINE 1、IRAK 1、IRAK 3、VEGFA、LY96、ANGPT 2、LBP、MicroRNA和mtDNA。在这篇综述中，我们讨论了先天免疫系统的模式识别受体，信号转导衔接蛋白和炎性细胞因子的基因。到目前为止，已经在创伤患者的队列中研究了许多遗传变异。研究往往是独特的，有时数字很小。关于特定序列变异对创伤患者结局的影响，目前还不能得出明确的结论。
Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. Increasing evidence suggests that genetic variants, particularly single nucleotide polymorphisms (SNPs), are critical determinants for interindividual differences in both inflammatory responses and clinical outcome in sepsis patients. Although the effect of SNPs on sepsis and MODS has been studied in many populations and diseases, this review aimed to summarize the current knowledge on the effect of SNPs on infectious complication specifically in trauma patients. A review of available literature was performed in PubMed database. The following genes have been studied in populations of trauma patients: CD14, HMGB1, IFNG, IL1A, IL1B, IL1RN, IL4, IL6, IL8, IL10, IL17F, IL18, MBL2, MASP2, FCN2, TLR1, TLR2, TLR4, TLR9, TNF, LTA, GR, MYLK, NLRP3, PRDX6, RAGE, HSPA1B, HSPA1L, HSP90, SERPINE1, IRAK1, IRAK3, VEGFA, LY96, ANGPT2, LBP, MicroRNA, and mtDNA. In this review, we discuss the genes of the Pattern Recognition Receptors, Signal Transducing Adaptor Proteins, and Inflammatory Cytokines of the innate immune system. A number of genetic variations have so far been studied in cohorts of trauma patients. Studies are often unique and numbers sometimes small. No definitive conclusions can be reached at this time about the influence of specific sequence variations on outcome in trauma patients.