Genetic and environmental influences on internalizing psychopathology across age and pubertal development.
Genetic and environmental influences on internalizing psychopathology across age and pubertal development.
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遗传和环境对跨年龄和青春期发育的内化精神病理学的影响。
DOI：
10.1037/dev0000578
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发表时间：
2018
影响因子：
4
通讯作者：
Harden,KPaige
中科院分区：
文献类型：
--
作者：
Patterson,MeganW;Mann,FrankD;Grotzinger,AndrewD;Tackett,JenniferL;Tucker-Drob,ElliotM;Harden,KPaige
焦虑和抑郁的症状通常是并存的，部分原因是遗传的。在过渡到青春期期间，焦虑和抑郁的平均水平会增加，特别是在女孩身上，这表明青春期发育在激活潜在的遗传风险方面可能起到了作用。目前的研究调查了遗传和环境对焦虑和抑郁的影响如何随年龄和青春期状态的不同而不同。我们分析了来自德克萨斯州双胞胎项目的1,913对来自1,006对双胞胎(年龄8-20岁)的种族和社会经济多样性样本的儿童自我报告和父母告密者的综合得分。生物测定模型测试了年龄和青春期状态作为焦虑和抑郁共有的遗传和环境影响的调节因素，以确定内化症状的病因是否作为年龄或青春期的函数在发育过程中有所不同。遗传影响并没有随着年龄或青春期的增加而增加，相反，共同的环境影响随着年龄的增长而减少。在同时考虑调节因素的探索性模型中，病因上的发育差异反映在抑郁症特有的遗传和环境影响上。结果表明，在青春期，内在化问题的遗传差异相对恒定，环境影响在不同的发育阶段更加不同。(心理信息数据库记录(C)2020 APA，版权所有)
Symptoms of anxiety and depression are commonly comorbid and partially share a genetic etiology. Mean levels of anxiety and depression increase over the transition to adolescence, particularly in girls, suggesting a possible role of pubertal development in the activation of underlying genetic risks. The current study examined how genetic and environmental influences on anxiety and depression differed by chronological age and pubertal status. We analyzed composite scores from child self-reports and parent informant-reports of internalizing symptomology in a racially and socioeconomically diverse sample of 1,913 individual twins from 1,006 pairs (ages 8–20 years) from the Texas Twin Project. Biometric models tested age and pubertal status as moderators of genetic and environmental influences shared between and specific to anxiety and depression to determine whether etiology of internalizing symptomology differs across development as a function of age or puberty. Genetic influences did not increase as a function of age or puberty, but instead shared environmental effects decreased with age. In an exploratory model that considered the moderators simultaneously, developmental differences in etiology were reflected in genetic and environmental effects unique to depression. Results suggest that genetic variance in internalizing problems is relatively constant during adolescence, with environmental influences more varied across development.(PsycInfo Database Record (c) 2020 APA, all rights reserved)