Efficacy of Omadacycline against Multidrug-Resistant Enterococcus faecium Strains in a Mouse Peritonitis Model.
Efficacy of Omadacycline against Multidrug-Resistant Enterococcus faecium Strains in a Mouse Peritonitis Model.
复制标题
奥马达环素在小鼠腹膜炎模型中对抗多重耐药屎肠球菌菌株的功效。
DOI：
10.1128/aac.00709-21
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发表时间：
2021
影响因子：
4.9
通讯作者：
Murray,BarbaraE
中科院分区：
文献类型：
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作者：
Singh,KavindraV;Arias,CesarA;Murray,BarbaraE
奥马环素（OMC）对Vanr、Ampr、DAP非敏感、利奈唑胺耐药、CFR（B）+屎肠球菌的体外效价优于达托霉素（DAP）和万古霉素（货车）。在小鼠腹膜炎模型中，OMC在研究期间和研究结束时也显示出比DAP或货车显著更好的动物存活率。粪菌菌株然而，OMC、DAP和货车对非万古霉素耐药、四环素耐药、DAP敏感的E.屎菌菌株
Omadacycline (OMC) showed betterin vitropotency than daptomycin (DAP) or vancomycin (VAN) against Vanr, Ampr, DAP-nonsusceptible, linezolid-resistant,cfr(B)+Enterococcus faecium strains. In a mouse peritonitis model, OMC also showed significantly better animal survival during the study and at its end than DAP or VAN with these E. faecium strains. However, OMC, DAP, and VAN showed comparablein vitroandin vivoefficacies against a non-vancomycin-resistant, tetracycline-resistant, DAP-susceptible E. faecium strain.