Experimental radiation pneumonitis. Radiographic and pathologic correlation
Experimental radiation pneumonitis. Radiographic and pathologic correlation
复制标题
实验性放射性肺炎。
作者：
Charles G. Stetson;J. Boland
对36只狗的小体积肺进行超高压照射。在一半动物中，通过3场波束定向技术暴露右肺门，在另一半动物中，通过楔形对技术暴露右下叶外周。剂量水平对应于5周内的4200、5600、6500和8400拉德。随后每月一次的X线片显示局部实变开始于3 - 6个月，6 - 12个月消退，随后出现纤维化。组织学检查显示胸膜增厚、炎性细胞浸润、肺泡化生和纤维化。影像学检查与组织学检查结果之间有良好的相关性。更高的剂量引起更严重的反应。在外围的变化发生更早，更严重的比在门。在6500拉德或更低的剂量下，12个月后获得了明显良好的健康状况。
A small volume of lung of 36 dogs was subjected to supervoltage irradiation. In half of the animals the hilum of the right lung was exposed by a 3‐field beamdirected technique and in the other half the periphery of the right lower lobe was exposed by a wedge pair technique. The dose levels corresponded to 4200, 5600, 6500, and 8400 rads in 5 weeks. Subsequent radiographs at monthly intervals showed localized consolidation beginning between 3 and 6 months resolving between 6 and 12 months with subsequent fibrosis. Histologic examination showed pleural thickening, inflammatory infiltration, alveolar metaplasia and fibrosis. There was good correlation between radiographic and histologic findings. Higher doses caused more severe reactions. Changes at the periphery occurred earlier and were more severe than at the hilum. Survival in apparent good health after 12 months was obtained at doses of 6500 rads or less.