STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
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DOI：
10.1038/374327a0
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发表时间：
1995-03-23
期刊：
影响因子：
64.8
通讯作者：
HENDRICKSON, WA
中科院分区：
文献类型：
--
作者：
SHAPIRO, L;FANNON, AM;HENDRICKSON, WA
N-钙粘蛋白的氨基末端结构域的晶体结构提供了细胞之间特异性粘附接触的原子水平的图像。一组重复的二聚体界面是三个晶格中的结构所共有的。这些相互作用联合收割机形成一个线性的分子拉链，反映了钙粘蛋白相关的细胞内细丝的线性结构。这种细胞粘附拉链可能提供了一种机制，将单个分子粘附相互作用编组为细胞之间的强键。
Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.