HER2/neu and Ki-67 as prognostic indicators in mucoepidermoid carcinoma of salivary glands
HER2/neu and Ki-67 as prognostic indicators in mucoepidermoid carcinoma of salivary glands
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DOI：
10.2310/7070.2003.11438
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发表时间：
2003-10-01
期刊：
影响因子：
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通讯作者：
Rochon, L
中科院分区：
文献类型：
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作者：
Nguyen, LHP;Black, MJ;Rochon, L
粘液表皮样癌是最常见的唾液腺恶性肿瘤，占所有病例的30%。尽管试图将组织病理学分级与临床结果联系起来，但一些组织学上“低”级别的病变尽管接受了适当的治疗，但仍表现出侵略性。目的：本初步研究将尝试评估免疫组织化学标志物HER2/neu和Ki-67作为涎腺粘液表皮样癌生物侵袭性的预后标志物。设计与方法：对1970年至1995年间收治的42例大小唾液腺粘液表皮样癌患者进行回顾性分析。采用一次切除加或不加术后放疗的联合治疗。提供了组织学分级和与结果的相关性分析。结果：在目前的研究中，HER2/neu阳性染色和Ki-67强染色发生在高级别黏液表皮样癌患者中，而低级别癌患者与阴性或弱染色相关。结论：这些初步结果表明，总体而言，HER2/neu和Ki-67癌蛋白的过表达可能是涎腺黏液表皮样癌预后不良的预后指标。
Introduction: Mucoepidermoid carcinoma is the most common salivary gland malignancy, representing up to 30% of all cases. Despite attempts to correlate histopathologic grades to clinical outcomes, some histologically "low"-grade lesions continue to behave aggressively despite appropriate treatment.Objective: This preliminary study will attempt to evaluate the use of immunohistochemical markers HER2/neu and Ki-67 as prognostic markers of biologic aggressiveness for mucoepidermoid carcinoma of the salivary glands.Design and Methods: A retrospective, chart review of 42 patients with mucoepidermoid carcinoma of major and minor salivary glands treated between 1970 and 1995 was conducted. A combination of primary resection with or without postoperative irradiation was used. Histologic grading and correlation with outcome analyses are provided.Results: In the current study, positive HER2/neu staining and strong Ki-67 staining occurred in patients with high-grade mucoepidermoid carcinoma, whereas low-grade carcinoma was correlated with negative or weak staining.Conclusion: These preliminary results indicate that, overall, the overexpression of both the HER2/neu and the Ki-67 oncoproteins may serve as prognostic markers for poor outcome in salivary gland mucoepidermoid carcinoma.