Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study.
Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: A retrospective cohort study.
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DOI：
10.1371/journal.pone.0248713
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Hoogerwerf J
中科院分区：
文献类型：
--
作者：
Pouw N;van de Maat J;Veerman K;Ten Oever J;Janssen N;Abbink E;Reijers M;de Mast Q;Hoefsloot W;van Crevel R;Slieker K;van Apeldoorn M;Blaauw M;Dofferhoff A;Hoogerwerf J
描述荷兰一个大型且记录良好的COVID-19住院患者队列的临床特征、病程和结局。我们在荷兰进行了一项多中心回顾性队列研究，包括2020年3月2日至2020年5月22日期间在参与医院住院的1183名连续住院患者中的952名。收集入院时和住院期间的临床特征和实验室参数，直至7月1日。中位年龄为69岁（IQR 58-77岁），605例（63.6%）为男性。558例（58.6%）患者存在心血管疾病。住院前症状发作的中位时间为7天（IQR 5-10）。非ICU入院政策适用于312例（32.8%）患者和165例（56.3%）入住病房的重症患者。在入院时和住院期间，重症患者的CRP、LDH、铁蛋白和D-二聚体值较高，中性粒细胞计数较高，淋巴细胞计数较低。总住院死亡率为25.1%，183例（19.1%）患者入住ICU，其中56例（30.6%）死亡。年龄≥70岁的患者在病房（52.4%）和ICU（47.4%）的死亡率较高。与年龄≤60岁的患者相比，年龄≥70岁的患者的ICU住院中位时间长8天。与≤60岁的患者相比，年龄≥70岁的COVID-19住院患者死亡率高，ICU住院时间长。这些发现结合ICU入院的患者负担和出院后可能的长期并发症，应鼓励我们进一步研究老年和脆弱的COVID-19患者的ICU入院益处。
To describe clinical characteristics, disease course and outcomes in a large and well-documented cohort of hospitalized COVID-19 patients in the Netherlands. We conducted a multicentre retrospective cohort study in The Netherlands including 952 of 1183 consecutively hospitalized patients that were admitted to participating hospitals between March 2nd, 2020, and May 22nd, 2020. Clinical characteristics and laboratory parameters upon admission and during hospitalization were collected until July 1st. The median age was 69 years (IQR 58–77 years) and 605 (63.6%) were male. Cardiovascular disease was present in 558 (58.6%) patients. The median time of onset of symptoms prior to hospitalization was 7 days (IQR 5–10). A non ICU admission policy was applicable in 312 (32.8%) patients and in 165 (56.3%) of the severely ill patients admitted to the ward. At admission and during hospitalization, severely ill patients had higher values of CRP, LDH, ferritin and D-dimer with higher neutrophil counts and lower lymphocyte counts. Overall in-hospital mortality was 25.1% and 183 (19.1%) patients were admitted to ICU, of whom 56 (30.6%) died. Patients aged ≥70 years had high mortality, both at the ward (52.4%) and ICU (47.4%). The median length of ICU stay was 8 days longer in patients aged ≥70 years compared to patients aged ≤60 years. Hospitalized COVID-19 patients aged ≥70 years had high mortality and longer ICU stay compared to patients aged ≤60 years. These findings in combination with the patient burden of an ICU admission and possible long term complications after discharge should encourage us to further investigate the benefit of ICU admission in elderly and fragile COVID-19-patients.
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影响因子：
8.8
作者：
Fan E;Dowdy DW;Colantuoni E;Mendez-Tellez PA;Sevransky JE;Shanholtz C;Himmelfarb CR;Desai SV;Ciesla N;Herridge MS;Pronovost PJ;Needham DM
通讯作者：
Needham DM
影响因子：
28.2
作者：
Liu, Yuwei;Du, Xuebei;Zhao, Yan
通讯作者：
Zhao, Yan
DOI：
10.1016/j.numecd.2020.07.031
发表时间：
2020-10-30
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Di Castelnuovo A;Bonaccio M;Costanzo S;Gialluisi A;Antinori A;Berselli N;Blandi L;Bruno R;Cauda R;Guaraldi G;My I;Menicanti L;Parruti G;Patti G;Perlini S;Santilli F;Signorelli C;Stefanini GG;Vergori A;Abdeddaim A;Ageno W;Agodi A;Agostoni P;Aiello L;Al Moghazi S;Aucella F;Barbieri G;Bartoloni A;Bologna C;Bonfanti P;Brancati S;Cacciatore F;Caiano L;Cannata F;Carrozzi L;Cascio A;Cingolani A;Cipollone F;Colomba C;Crisetti A;Crosta F;Danzi GB;D'Ardes D;de Gaetano Donati K;Di Gennaro F;Di Palma G;Di Tano G;Fantoni M;Filippini T;Fioretto P;Fusco FM;Gentile I;Grisafi L;Guarnieri G;Landi F;Larizza G;Leone A;Maccagni G;Maccarella S;Mapelli M;Maragna R;Marcucci R;Maresca G;Marotta C;Marra L;Mastroianni F;Mengozzi A;Menichetti F;Milic J;Murri R;Montineri A;Mussinelli R;Mussini C;Musso M;Odone A;Olivieri M;Pasi E;Petri F;Pinchera B;Pivato CA;Pizzi R;Poletti V;Raffaelli F;Ravaglia C;Righetti G;Rognoni A;Rossato M;Rossi M;Sabena A;Salinaro F;Sangiovanni V;Sanrocco C;Scarafino A;Scorzolini L;Sgariglia R;Simeone PG;Spinoni E;Torti C;Trecarichi EM;Vezzani F;Veronesi G;Vettor R;Vianello A;Vinceti M;De Caterina R;Iacoviello L;COvid-19 RISk and Treatments (CORIST) collaboration
通讯作者：
COvid-19 RISk and Treatments (CORIST) collaboration
影响因子：
76.2
作者：
Ronco, Claudio;Reis, Thiago;Husain-Syed, Faeq
通讯作者：
Husain-Syed, Faeq
影响因子：
120.7
作者：
Sprung, CL;Cohen, SL;Woodcock, T
通讯作者：
Woodcock, T