Current Approaches for Drug Delivery to Central Nervous System
Current Approaches for Drug Delivery to Central Nervous System
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DOI：
10.2174/156720110793566245
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发表时间：
2010-12-01
影响因子：
2.4
通讯作者：
Chowdhury, Ezharul Hoque
中科院分区：
文献类型：
--
作者：
Hossain, Sharif;Akaike, Toshihiro;Chowdhury, Ezharul Hoque
脑是脊椎动物神经系统的中枢，对人体的各项功能起着至关重要的作用。然而，随着人口老龄化，许多神经退行性疾病、癌症和脑部感染变得更加普遍。尽管神经科学取得了重大进展，但由于脊椎动物脑毛细血管内皮内的紧密连接形成的血脑屏障（BBB），许多潜在的治疗剂仍然无法到达中枢神经系统（CNS）。这导致毛细管壁表现为连续的脂质双层，并阻止极性和脂不溶性物质通过。已经开发了几种用于将药物递送至CNS的方法，以通过修饰药物本身或通过将其偶联至用于受体介导的、载体介导的或吸附介导的转胞吞作用的载体来增强治疗性分子穿过BBB的能力。目前的挑战是开发药物递送系统，以确保药物安全有效地通过血脑屏障。本文综述了近年来提高药物向中枢神经系统转运的策略和方法。
Brain, the center of the nervous system in all vertebrate, plays the most vital role in every function of human body. However, many neurodegenerative diseases, cancer and infections of the brain become more prevalent as populations become older. In spite of the major advances in neuroscience, many potential therapeutics are still unable to reach the central nervous system (CNS) due to the blood-brain barrier (BBB) which is formed by the tight junctions within the capillary endothelium of the vertebrate brain. This results in the capillary wall behaving as a continuous lipid bilayer and preventing the passage of polar and lipid insoluble substances. Several approaches for delivering drugs to the CNS have been developed to enhance the capacity of therapeutic molecules to cross the BBB by modifying the drug itself, or by coupling it to a vector for receptor-mediated, carrier mediated or adsorption-mediated transcytosis. The current challenge is to develop drug delivery systems that ensure the safe and effective passage of drugs across the BBB. This review focuses on the strategies and approaches developed to enhance drug delivery to the CNS.