Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis
Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis
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DOI：
10.2169/internalmedicine.55.6943
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发表时间：
2016-01-01
影响因子：
1.2
通讯作者：
Takeuchi, Tsutomu
中科院分区：
文献类型：
--
作者：
Kikuchi, Jun;Kaneko, Yuko;Takeuchi, Tsutomu
血管内大B细胞淋巴瘤（IVLBCL）是一种罕见的临床侵袭性淋巴瘤，预后不良。我们报告的情况下，50岁的妇女谁被诊断为IVLBCL治疗期间与甲氨蝶呤（MTX）和生物制剂类风湿关节炎。仅在停止两种治疗后症状才部分改善。她随后接受了化疗，并取得了完全缓解，并保持了2年没有复发，没有任何进一步的治疗。我们在此描述一个罕见的情况下，IVLBCL提出的特点与甲氨蝶呤相关的淋巴增生性疾病。
Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.