Characteristics of Higher-Order Aberrations in Different Stages of Keratoconus
Characteristics of Higher-Order Aberrations in Different Stages of Keratoconus
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DOI：
10.1097/icl.0000000000000897
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发表时间：
2022-06-01
影响因子：
2.3
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
--
作者：
Koh, Shizuka;Inoue, Ryota;Nishida, Kohji
目的：研究临床和亚临床圆锥角膜（KC）的高阶像差（HOA）特征。研究方法：该研究包括33，36和26例患者的临床，地形（无临床体征），和pretopographic（正常地形，无临床体征）KC和30名对照。使用波前传感器测量4 mm瞳孔的眼睛和角膜HOA，并扩展到Zernike多项式的六阶。通过Zernike矢量分析计算三叶形、彗差、四叶形、次级散光和球面像差的大小，并将其用作HOA参数沿着总HOA。比较术前KC的每个波前参数的受试者工作特征曲线下面积（AUROC）值。结果如下：对照眼和术前角膜地形图KC的眼或角膜总HOA和Zernike向量项均显著低于临床KC和地形KC，但所有组中地形KC和术前角膜地形图KC之间的眼四叶像差和球面像差除外。角膜地形图前KC和对照眼的角膜总HOA和角膜昏迷的AUROC分别为0.781（100%灵敏度和47%特异性）和0.735（73%灵敏度和73%特异性）。结论：角膜总HOA和角膜昏迷显示出潜在的能力，以区分术前KC正常对照眼。
Objectives: To characterize higher-order aberrations (HOAs) in clinical and subclinical keratoconus (KC). Methods: The study included 33, 36, and 26 patients with clinical, topographic (no clinical signs), and pretopographic (normal topography and no clinical signs) KC and 30 controls. Ocular and corneal HOAs for the 4-mm pupils were measured using a wavefront sensor and expanded up to the sixth order of Zernike polynomials. The magnitudes of trefoil, coma, tetrafoil, secondary astigmatism, and spherical aberration were calculated via Zernike vector analysis and used as HOA parameters along with total HOAs. Area under the receiver operating characteristic curve (AUROC) values for each wavefront parameter for pretopographic KC were compared. Results: Control eyes and eyes with pretopographic KC had significantly lower ocular or corneal total HOAs and Zernike vector terms than those with clinical KC and topographic KC, except for ocular tetrafoil between topographic KC and pretopographic KC and spherical aberration among all groups. The AUROCs for corneal total HOAs and corneal coma for pretopographic KC and control eyes were 0.781 (100% sensitivity and 47% specificity) and 0.735 (73% sensitivity and 73% specificity), respectively. Conclusion: Corneal total HOAs and corneal coma exhibited a potential ability to discriminate pretopographic KC from normal control eyes.