Targeting the hypoxia pathway to treat pancreatic cancer.
Targeting the hypoxia pathway to treat pancreatic cancer.
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DOI：
10.2147/dddt.s80888
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Erickson LA;Highsmith WE Jr;Fei P;Zhang J
缺氧和胰腺癌之间的相关性已经讨论了很久。近年来，Hao的研究小组在揭示缺氧诱导因子-1（HIF-1）在胰腺癌进展和发展中的致癌功能方面做了大量工作。基于他们的研究，他们将胰腺癌的微环境调节及其临床意义联系起来。Hao的研究小组认为，靶向HIF-1是一种很有前途的方法，用于控制胰腺癌的进展和侵袭。
The correlation between hypoxia and pancreatic cancer has long been discussed. Hao’s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao’s research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.