Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure
Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure
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DOI：
10.1016/j.janxdis.2008.12.005
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发表时间：
2009-04-01
影响因子：
10.3
通讯作者：
Gelernter, Joel
中科院分区：
文献类型：
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作者：
Amstadter, Ananda B.;Koenen, Karestan C.;Gelernter, Joel
RGS 2（G蛋白信号调节因子2）基因的多态性被发现与小鼠的焦虑行为和人类的焦虑有关。我们在一个流行病学样本中研究了rs 4606（RGS 2的单核苷酸多态性）和社会支持是否能调节PTSD的风险。该研究调查了2004年佛罗里达飓风研究中通过邮件返回口腔DNA样本的607名成年人。在高飓风暴露和低社会支持的条件下，rs 4606与灾后PTSD症状的增加有关（P <0.05）。此外，在终生暴露于潜在创伤事件和低社会支持的条件下，这种多态性与终生PTSD症状相关（P <0.001）。在调整性别、血统和年龄后，这些基因与环境的相互作用仍然显着。RGS 2 rs 4606在高应激暴露条件下改变灾后和终生PTSD症状的风险。这是该基因座的基因-环境相互作用的第一个证明。(C)2008爱思唯尔有限公司保留所有权利。
Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were found to be associated with anxious behavior in mice and anxiety in humans. We examined whether rs4606, a single nucleotide polymorphism (SNP) of RGS2, and social support moderated risk for PTSD in an epidemiologic sample. The study examines 607 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. rs4606 was associated with increased symptoms of posthurricane PTSD symptoms under conditions of high hurricane exposure and low social support (P < .05). Further, this polymorphism was associated with lifetime PTSD symptoms under conditions of lifetime exposure to a potentially traumatic event, and low social support (P < .001). These gene by environment interactions remained significant after adjustment for sex, ancestry, and age. RGS2 rs4606 modifies risk of postdisaster and lifetime PTSD symptoms under conditions of high stressor exposure. This is the first demonstration of gene-environment interaction for this locus. (C) 2008 Elsevier Ltd. All rights reserved.