Modelling tissue electrophysiology with multiple cell types: applications of the extended bidomain framework
Modelling tissue electrophysiology with multiple cell types: applications of the extended bidomain framework
复制标题
DOI：
10.1039/c2ib00100d
复制
发表时间：
2012-01-01
影响因子：
2.5
通讯作者：
Buist, Martin L.
中科院分区：
文献类型：
--
作者：
Corrias, Alberto;Pathmanathan, Pras;Buist, Martin L.
bidomain框架已被广泛用于各种应用中的组织电生理学建模。bidomain模型的一个局限性是它只描述了一种细胞类型与细胞外空间相互作用的活性。如果一种以上的细胞类型有助于组织电生理学，那么双脉模型是不够的。最近，有证据表明，这是至少两个重要的应用情况：心脏和胃肠道组织电生理学。在心脏中，成纤维细胞普遍与肌细胞相互作用，并且被认为在器官电生理学中起重要作用。沿着胃肠道，卡哈尔间质细胞（ICC）产生电波，该电波传递到周围的平滑肌细胞（SMC），平滑肌细胞与ICC相互连接。由于不止一种细胞类型对整个器官电生理学的贡献，不同领域的研究人员独立地提出了类似的扩展bidomain模型，以纳入多种细胞类型，并在简化的几何形状上进行了测试。在本文中，我们提供了这样一个扩展的bidomain框架适用于任何组织的一般推导，并提供了适用于任何几何形状的通用和有效的实现。使用扩展的bidomain框架上的现实的3D器官几何结构的组织电生理学的概念验证结果的心脏和胃。
The bidomain framework has been extensively used to model tissue electrophysiology in a variety of applications. One limitation of the bidomain model is that it describes the activity of only one cell type interacting with the extracellular space. If more than one cell type contributes to the tissue electrophysiology, then the bidomain model is not sufficient. Recently, evidence has suggested that this is the case for at least two important applications: cardiac and gastrointestinal tissue electrophysiology. In the heart, fibroblasts ubiquitously interact with myocytes and are believed to play an important role in the organ electrophysiology. Along the GI tract, interstitial cells of Cajal (ICC) generate electrical waves that are passed on to surrounding smooth muscle cells (SMC), which are interconnected with the ICC and with each other. Because of the contribution of more than one cell type to the overall organ electrophysiology, investigators in different fields have independently proposed similar extensions of the bidomain model to incorporate multiple cell types and tested it on simplified geometries. In this paper, we provide a general derivation of such an extended bidomain framework applicable to any tissue and provide a generic and efficient implementation applicable to any geometry. Proof-of-concept results of tissue electrophysiology on realistic 3D organ geometries using the extended bidomain framework are presented for the heart and the stomach.