The assessment of refill compliance using pharmacy records: Methods, validity, and applications
The assessment of refill compliance using pharmacy records: Methods, validity, and applications
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DOI：
10.1016/s0895-4356(96)00268-5
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发表时间：
1997-01-01
影响因子：
7.2
通讯作者：
Prochazka, AV
中科院分区：
文献类型：
--
作者：
Steiner, JF;Prochazka, AV
计算机化药房系统的续装记录越来越多地被用作合规信息的来源。我们回顾了英文文献，以开发评估再填充依从性(RC)的方法的类型学，描述获得药物依从性的流行病学，识别试图验证RC措施的研究，描述预测RC的临床特征，并描述RC措施在流行病学和卫生服务研究中的使用。在审查的41项研究中，大多数患者获得的药物比处方的少；治疗缺口很常见。在评估RC措施有效性的研究中，大多数发现RC与其他遵从性措施以及药物存在(例如血清药物水平)或生理药物效果的措施之间存在显著关联。充填依从性通常与研究人群的人口统计特征无关，在每日剂量较少的药物中较高，并且与开出的药物总数不一致。我们的结论是，尽管一些方法学问题需要进一步研究，但在直接测量药物消耗不可行的情况下，RC测量在基于人群的研究中可以是一个有用的依从性信息来源。版权所有(C)1997爱思唯尔科学公司。
The refill records of computerized pharmacy systems are used increasingly as a source of compliance information. We reviewed the English-language literature to develop a typology of methods for assessing refill compliance (RC), to describe the epidemiology of compliance in obtaining medications, to identify studies that attempted to validate RC measures, to describe clinical features that predicted RC, and to describe the uses of RC measures in epidemiologic and health services research. In most of the 41 studies reviewed, patients obtained less medication than prescribed; gaps in treatment were common. Of the studies that assessed the validity of RC measures, most found significant associations between RC and other compliance measures, as well as measures of drug presence (e.g., serum drug levels) or physiologic drug effects. Refill compliance was generally not correlated with demographic characteristics of study populations, was higher among drugs with fewer daily doses, and was inconsistently associated with the total number of drugs prescribed. We conclude that, though some methodologic problems require further study, RC measures can be a useful source of compliance information in population based studies when direct measurement of medication consumption is not feasible. Copyright (C) 1997 Elsevier Science Inc.