NOSOCOMIAL HERPETIC INFECTIONS IN A PEDIATRIC INTENSIVE-CARE UNIT
NOSOCOMIAL HERPETIC INFECTIONS IN A PEDIATRIC INTENSIVE-CARE UNIT
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DOI：
10.1093/oxfordjournals.aje.a113076
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发表时间：
1981-01-01
影响因子：
5
通讯作者：
STEWART, JA
中科院分区：
文献类型：
--
作者：
ADAMS, G;STOVER, BH;STEWART, JA
一系列急性疱疹病毒感染发生在儿科重症监护病房（PICU）的护士和病人之间。流行病学调查显示两个独立的时间集群感染，一个在初夏，另一个在6周后。从病毒分离株中提取的DNA的限制性内切酶分析表明，每个时间簇与不同的遗传株的单纯疱疹病毒（HSV）1型，并提供证据的病人和护士之间的交叉感染。三名护士患有疱疹性Whitlow;一名护士的丈夫患有急性牙龈口炎;第四名护士患有急性咽炎。他们以前没有HSV感染史，对受影响的护士进行的连续抗体检测显示，所有初始阳性血清中均存在19 S抗体，证实了原发感染。这些数据提供了明确的证据表明，除非采取特别的预防措施，否则PICU人员有可能从患者那里获得严重的疱疹感染，反之亦然。HSV DNA的限制性内切酶分析有助于流行病学研究。
A series of acute herpetic infections occurred among nurses and patients in a pediatric intensive care unit (PICU). Epidemiologic study revealed 2 separate time clusters of infections, one in early summer and another 6 wk later. Restriction endonuclease analysis of DNA extracted from virus isolates showed that each time cluster was associated with a different genetic strain of herpes simplex virus (HSV) type 1 and provided evidence of cross infection between patients and nurses. Three nurses had herpetic whitlow; the husband of one had acute gingivostomatitis; a 4th nurse had acute pharyngitis. They had no previous history of HSV infection and sequential antibody testing of affected nurses showed 19S antibody in all initially positive serums, confirming primary infection. The data provide clear evidence that PICU personnel risk acquiring serious herpetic infections from patients and vice versa unless specific precautions are taken. Restriction endonuclease analysis of HSV DNA was useful in the epidemiologic study of the infections.