Cholinergic regulation of keratinocyte innate immunity and permeability barrier integrity: new perspectives in epidermal immunity and disease.
Cholinergic regulation of keratinocyte innate immunity and permeability barrier integrity: new perspectives in epidermal immunity and disease.
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DOI：
10.1038/jid.2011.264
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Radek KA
中科院分区：
文献类型：
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作者：
Curtis BJ;Radek KA
几种皮肤炎症性疾病及其临床表型在皮肤病的动物模型中得到了概括。然而，疾病进展的共同途径的识别受到描述疾病发展基础的复杂生化过程的能力的限制。确定皮肤炎症和免疫功能的共同信号通路将有助于更好的科学和治疗策略，以跨越各种炎症性皮肤病。抗菌肽（AMP）的异常表达和活性是多种炎症性皮肤病发生和严重程度背后的机制之一，并直接影响皮肤对微生物感染的易感性。我们的研究最近揭示了一种新发现的途径，即通过乙酰胆碱（ACh）的胆碱能抗炎途径对皮肤中的AMPs进行负调控。本文综述了乙酰胆碱在AMP调节角质形成细胞免疫和通透性屏障功能中的作用，并讨论了通过胆碱能信号传导更好地理解皮肤疾病进展的重要性。
Several cutaneous inflammatory diseases and their clinical phenotypes are recapitulated in animal models of skin disease. However, the identification of shared pathways for disease progression is limited by the ability to delineate the complex biochemical processes fundamental for development of the disease. Identifying common signaling pathways that contribute to cutaneous inflammation and immune function will facilitate better scientific and therapeutic strategies to span a variety of inflammatory skin diseases. Aberrant antimicrobial peptide (AMP) expression and activity is one mechanism behind the development and severity of several inflammatory skin diseases and directly influences the susceptibility of skin to microbial infections. Our studies have recently exposed a newly identified pathway for negative regulation of AMPs in the skin by the cholinergic anti-inflammatory pathway via acetylcholine (ACh). The role of ACh in AMP regulation of immune and permeability barrier function in keratinocytes is reviewed, and the importance for a better comprehension of cutaneous disease progression by cholinergic signaling is discussed.