Temporal dynamics of verbal object comprehension
Temporal dynamics of verbal object comprehension
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DOI：
10.1073/pnas.95.11.6498
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发表时间：
1998-05-26
影响因子：
11.1
通讯作者：
Gordon, B
中科院分区：
文献类型：
--
作者：
Hart, J;Crone, NE;Gordon, B
人类认知活动的阶段构成和时间动态的知识对于建立高级心理活动理论至关重要。这些信息很难获得，即使使用不同的技术组合，如精细的行为测试，电记录/干扰和代谢成像研究。本研究采用三种任务对单个个体的言语客体理解进行了研究（物体命名、听觉单词理解和视觉单词理解），两种语言（英语和波斯语），以及四种技术（刺激操作、直接皮层电干扰、皮层电描记术和直接皮层电干扰技术的变体，以产生时间限定的效应，称为时间切片），为了临床目的，在受试者体内放置了留置硬膜下电极阵列。电干扰：左枕颞外侧回的一对电极干扰两种语言的命名和被测语言（英语）的理解，命名和理解缺陷是由于对动词对象意义的处理受到干扰。命名期间该部位皮质激活的皮质电图指数在视觉刺激呈现后250-300毫秒开始。通过使用的时间切片技术，这改变了发病的电干扰相对于行为的任务，我们发现，完成处理的言语对象的含义从450到750毫秒后，电流发作。这种变化被认为是一个函数的主题的熟悉的对象。
Knowledge of the stage composition and the temporal dynamics of human cognitive operations is critical for building theories of higher mental activity. This information has been difficult to acquire, even with different combinations of techniques such as refined behavioral testing, electrical recording/interference, and metabolic imaging studies. Verbal object comprehension was studied herein in a single individual, by using three tasks (object naming, auditory word comprehension, and visual word comprehension), two languages (English and Farsi), and four techniques (stimulus manipulation, direct cortical electrical interference, electrocorticography, and a variation of the technique of direct cortical electrical interference to produce time-delimited effects, called timeslicing), in a subject in whom indwelling subdural electrode arrays had been placed for clinical purposes. Electrical interference :It a pair of electrodes on the left lateral occipitotemporal gyrus interfered with naming in both languages and with comprehension in the language tested (English), The naming and comprehension deficit resulted from interference with processing of verbal object meaning. Electrocorticography indices of cortical activation at this site during naming started 250-300 msec after visual stimulus presentation. By using the timeslicing technique, which varies the onset of electrical interference relative to the behavioral task, we found that completion of processing for verbal object meaning varied from 450 to 750 msec after current onset. This variability was found to be a function of the subject's familiarity with the objects.