Strain and torsion quantification in mouse hearts under dobutamine stimulation using 2D multiphase MR DENSE.
Strain and torsion quantification in mouse hearts under dobutamine stimulation using 2D multiphase MR DENSE.
复制标题
使用 2D 多相 MR DENSE 对多巴酚丁胺刺激下的小鼠心脏应变和扭转进行定量。
DOI：
10.1002/mrm.22530
复制
发表时间：
2010
影响因子：
3.3
通讯作者：
Yu,Xin
中科院分区：
文献类型：
--
作者：
Zhong,Jia;Yu,Xin
在这项研究中，一个二维多相磁共振位移编码与刺激回波（DENSE）成像和分析方法，直接量化的拉格朗日应变在小鼠心脏。使用所提出的方法，实现了<10 ms的时间分辨率和0.56 mm的面内分辨率。一项验证研究比较了通过位移编码与刺激回波和通过磁共振标记进行的应变计算，结果表明两种方法之间具有高度相关性（R2> 0.80）。局部心室壁应变和扭曲的特点是在小鼠心脏在基线和多巴酚丁胺刺激。多巴酚丁胺刺激引起的径向和周向应变和扭转在峰值收缩显着增加。在早期的螺旋中也观察到快速解旋。这项工作表明，在小鼠心脏多巴酚丁胺刺激使用2D多相磁共振位移编码与刺激回波表征心脏功能反应的能力。Magn Reson Med，2010年。© 2010 Wiley利斯公司
In this study, a 2D multiphase magnetic resonance displacement encoding with stimulated echoes (DENSE) imaging and analysis method was developed for direct quantification of Lagrangian strain in the mouse heart. Using the proposed method, <10 ms temporal resolution and 0.56 mm in‐plane resolution were achieved. A validation study that compared strain calculation by displacement encoding with stimulated echoes and by magnetic resonance tagging showed high correlation between the two methods (R2> 0.80). Regional ventricular wall strain and twist were characterized in mouse hearts at baseline and under dobutamine stimulation. Dobutamine stimulation induced significant increase in radial and circumferential strains and torsion at peak systole. A rapid untwisting was also observed during early diastole. This work demonstrates the capability of characterizing cardiac functional response to dobutamine stimulation in the mouse heart using 2D multiphase magnetic resonance displacement encoding with stimulated echoes. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.