The influence of sex steroids on the sexual size dimorphism in the red-spotted garter snake, Thamnophis sirtalis concinnus.
The influence of sex steroids on the sexual size dimorphism in the red-spotted garter snake, Thamnophis sirtalis concinnus.
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性类固醇对红斑袜带蛇 Thamnophis Sirtalis concinnus 性别大小二态性的影响。
DOI：
10.1006/gcen.2001.7695
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发表时间：
2001
影响因子：
2.7
通讯作者：
Robert T. Mason
中科院分区：
文献类型：
--
作者：
Darren T. Lerner;Robert T. Mason
红色斑点吊袜蛇表现出成体大小的二型性，其中雌性是较大的性别。为了了解哪些激素可能影响该物种的差异生长，我们绘制了雄性和雌性新生儿的生长曲线和雌雄激素的生长曲线和激素谱。生长是通过植入外源激素和激素拮抗剂来控制的。从出生20周或24周开始，女婴的体重会更重，也会更长。虽然从出生到15周大的男性和女性都存在低水平的E2和T循环，但这些水平在性别之间没有显著差异。24周龄后，处理组和未处理组的生长曲线差异显著。抗雌激素在女性中产生了类似男性的生长，但对男性没有影响。抗雄激素对男性和女性都没有影响。外源T降低雌性与雄性的生长，而雌二醇降低雄性的生长。这些结果表明，对于男性来说，基础水平的E2或T足以保持典型的男性生长模式。类似的内源性雌激素水平似乎对女性有促进生长的作用。内源性T似乎不会对女性的生长发育起作用。
The red-spotted garter snake exhibits adult size dimorphism in which females are the larger sex. To understand which hormones may influence differential growth in this species, growth curves and hormone profiles of estradiol-17beta (E2) and testosterone (T) were constructed in male and female neonates. Growth was manipulated via implantation of exogenous hormones and hormone antagonists. Female neonates are heavier or longer beginning at either 20 or 24 weeks of age, respectively. Although low circulating levels of E2 and T were present in males and females from birth through 15 weeks of age, these levels were not significantly different between the sexes. Differences in the growth curves of the treated and untreated snakes were significant after 24 weeks of age. Antiestrogen produced male-like growth in females but had no effect on males. Antiandrogen had no effect on either males or females. Exogenous T reduced female growth to that observed in males, and E2 reduced male growth. These results suggest that a basal level of either E2 or T is sufficient in males to retain typical male growth patterns. Similar endogenous levels of E2 appear to have growth-promoting effects in females. Endogenous T does not appear to play a role in female growth.
成人短期暴露于雌二醇会使大鼠自发和生长激素释放因子刺激的生长激素分泌的男性模式女性化。
影响因子：
4.8
作者：
Painson,JC;Thorner,MO;Krieg,RJ;Tannenbaum,GS
通讯作者：
Tannenbaum,GS