Induction of skin sensitization is augmented in Nrf2-deficient mice
Induction of skin sensitization is augmented in Nrf2-deficient mice
复制标题
Nrf2 缺陷小鼠皮肤过敏的诱导增强
作者：
J. Veen;E. Gremmer;J. Vermeulen;H. Loveren;J. Ezendam
几项体外DNA微阵列研究表明核因子（红细胞衍生2）样2（Nrf 2）在皮肤致敏中的重要性。然而，Nrf 2-Keap 1通路在皮肤致敏诱导过程中的确切体内作用仍然未知。为了研究Nrf 2的功能，使用2，4-二硝基氯苯在野生型和Nrf 2缺陷小鼠中进行了局部淋巴结测定。Nrf 2缺陷小鼠表现出更明显的反应，表明Nrf 2参与抑制皮肤致敏的诱导。
Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study the function of Nrf2, a local lymph node assay was performed in wild-type and Nrf2-deficient mice using 2,4-dinitrochlorobenzene. The Nrf2-deficient mice show a more pronounced response, indicating that Nrf2 is involved in dampening the induction of skin sensitization.
DOI：
10.1073/pnas.93.24.13943
发表时间：
1996-11-26
影响因子：
11.1
作者：
Chan, KM;Lu, RH;Kan, YW
通讯作者：
Kan, YW