T Regulatory Lymphocytes Prevent Angiotensin II-Induced Hypertension and Vascular Injury
T Regulatory Lymphocytes Prevent Angiotensin II-Induced Hypertension and Vascular Injury
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DOI：
10.1161/hypertensionaha.110.162941
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发表时间：
2011-03-01
期刊：
影响因子：
8.3
通讯作者：
Schiffrin, Ernesto L.
中科院分区：
文献类型：
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作者：
Barhoumi, Tlili;Kasal, Daniel A.;Schiffrin, Ernesto L.
血管紧张素（Ang） II诱导高血压的机制部分由适应性免疫和T效应淋巴细胞介导。T调节性淋巴细胞（Tregs）抑制T效应淋巴细胞。我们质疑Treg过继移植是否会减弱Ang ii诱导的高血压和血管损伤。10 ~ 12周龄雄性C57BL/6小鼠静脉注射3 × 10(5)个Treg (CD4（+)CD25(+)）或T效应(CD4（+)CD25(-)）细胞，每2周注射3次，然后分别输注或不输注Ang II (1 μ g/kg / min， SC)，持续14天。angii使收缩压升高43 mm Hg (P
Angiotensin (Ang) II induces hypertension by mechanisms mediated in part by adaptive immunity and T effector lymphocytes. T regulatory lymphocytes (Tregs) suppress T effector lymphocytes. We questioned whether Treg adoptive transfer would blunt Ang II-induced hypertension and vascular injury. Ten-to 12-week-old male C57BL/6 mice were injected IV with 3 x 10(5) Treg (CD4(+)CD25(+)) or T effector (CD4(+)CD25(-)) cells, 3 times at 2-week intervals, and then infused or not with Ang II (1 mu g/kg per minute, SC) for 14 days. Ang II increased systolic blood pressure by 43 mm Hg (P