MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential
MicroRNAs in breast cancer: oncogene and tumor suppressors with clinical potential
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DOI：
10.1631/jzus.b1400184
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发表时间：
2015-01-01
影响因子：
5.1
通讯作者：
Luo, Yun-ping
中科院分区：
文献类型：
--
作者：
Wang, Wei;Luo, Yun-ping
microRNA（miRs）是一类小的单链RNA分子，在几乎所有的生物学过程中起着转录后调控的关键负调控因子的作用。已经在包括乳腺癌在内的各种类型的癌症中观察到microRNA的异常表达。人们已经做了很大的努力来确定microRNA表达谱与乳腺癌之间的关联，并了解异常表达的microRNA的功能作用和分子机制。随着研究的进展，“致癌microRNA”和“肿瘤抑制microRNA”成为关注的焦点。来自细胞间（组织）和细胞外（血清）来源的候选microRNA用于临床诊断和预后的潜力被揭示出来，涉及microRNA的治疗在癌症疾病模型中取得了一些惊人的疗效。在这篇综述中，从最新的研究进展的microRNA在最常见的癌症之一，乳腺癌，强调，特别是功能的特定选择的microRNA。我们还评估了这些microRNA作为诊断和预后标志物的潜在价值，并讨论了基于microRNA的疗法的可能发展。
MicroRNAs (miRs) are small single-stranded RNA molecules, which function as key negative regulators of post-transcriptional modulation in almost all biological processes. Abnormal expression of microRNAs has been observed in various types of cancer including breast cancer. Great efforts have been made to identify an association between microRNA expression profiles and breast cancer, and to understand the functional role and molecular mechanism of aberrant-expressed microRNAs. As research progressed, 'oncogenic microRNAs' and 'tumor suppressive microRNAs' became a focus of interest. The potential of candidate microRNAs from both intercellular (tissue) and extracellular (serum) sources for clinical diagnosis and prognosis was revealed, and treatments involving microRNA achieved some amazing curative effects in cancer disease models. In this review, advances from the most recent studies of microRNAs in one of the most common cancers, breast cancer, are highlighted, especially the functions of specifically selected microRNAs. We also assess the potential value of these microRNAs as diagnostic and prognostic markers, and discuss the possible development of microRNA-based therapies.