Axon Reflex Vasodilatation in Cat Dental Pulp Elicited by Noxious Stimulation of the Gingiva
Axon Reflex Vasodilatation in Cat Dental Pulp Elicited by Noxious Stimulation of the Gingiva
复制标题
牙龈有害刺激引起的猫牙髓轴突反射血管舒张
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
K. Karita
中科院分区：
文献类型：
--
作者：
T. Sasano;S. Kuriwada;N. Shoji;D. Sanjo;H. Izumi;K. Karita
对感觉神经的反向刺激已被证明能增加它们所支配的组织的血流量。本研究旨在确定猫牙髓是否发生反节律血管舒缩反应，以及它们是否由供应牙髓和牙龈的分支轴突介导。采用激光多普勒测速仪研究了电刺激、挤压、加热和辣椒素对猫下颌骨犬牙髓血流量的影响。所有下肺泡神经束和颈交感干均已事先切除，以避免脑干反射的发生，如躯体-自主血管舒张反射。在12只猫中，有7只猫的PBF增加，当犬齿附近的受限牙龈区域受到如上所述的刺激时，但在敏感的牙龈区域涂上利多卡因果冻（一种表面麻醉剂）后，PBF的增加被消除。这些血管舒张反应，在重复施用30mm辣椒素后显著减少，被认为是通过辣椒素敏感的伤害性神经纤维的反向激活诱导的，可能是通过轴突反射机制，这表明供应牙龈的神经末梢起源于母轴突，母轴突具有支配犬牙髓的侧支。
Antidromic stimulation of sensory nerves has been shown to increase blood flow in the tissue they innervate. This study was designed to determine if antidromic vasomotor responses occur in feline dental pulp and if they are mediated by branched axons supplying both tooth pulp and gingiva. Dynamic changes in pulpal blood flow (PBF) elicited by electrical stimulation, pinching, heating, and capsaicin application to the gingivae were investigated in cat mandibular canine teeth by means of Laser Doppler Velocimetry. All inferior alveolar nerve bundles and the cervical sympathetic trunk had been previously sectioned to avoid the occurrence of brainstem reflexes, e.g., somato-autonomic vasomotor reflexes. Increases in PBF were observed in seven out of 12 cats when a restricted gingival area adjacent to the canine teeth was stimulated as described, but the increases were abolished after the sensitive gingival area was painted with lidocaine jelly, a surface anesthetic. These vasodilator responses, remarkably reduced following repeated application of 30 mM of capsaicin, are considered to be induced via antidromic activation of capsaicin-sensitive nociceptive nerve fibers, presumably by axon reflex mechanisms, suggesting that nerve terminals supplying the gingiva originate from parent axons which have collaterals that innervate the canine tooth pulp.
牙髓的血流动力学。
影响因子：
7.6
作者：
Chien,S
通讯作者：
Chien,S
激光多普勒法和 133 氙冲洗法测定的犬齿牙髓血流量的比较。
影响因子：
3
作者：
Kim,S;Liu,M;Markowitz,K;Bilotto,G;Dörscher-Kim,J
通讯作者：
Dörscher-Kim,J