G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.
G protein-coupled receptors and adipogenesis: a focus on adenosine receptors.
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DOI：
10.1002/jcp.24473
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发表时间：
2014-04
影响因子：
5.6
通讯作者：
Ravid, Katya
中科院分区：
文献类型：
--
作者：
Eisenstein, Anna;Ravid, Katya
G蛋白偶联受体（GPCR）是一个大家族的蛋白质，协调细胞外信号产生生理结果。腺苷受体（AR）是一类GPCR，已被证明可调节炎症、血流和细胞分化等多种功能。腺苷通过四种GPCR信号传导，其抑制（A1AR和A3AR）或激活（A2aAR和A2bAR）腺苷酸环化酶。本文将重点介绍GPCR，特别是腺苷受体在脂肪形成中的作用。前脂肪细胞分化为成熟脂肪细胞，因为脂肪组织膨胀以补偿过量营养素的消耗。这些新生成的脂肪细胞有助于维持代谢稳态。了解这种分化过程的关键驱动因素可以帮助开发治疗方法，以对抗日益增长的肥胖流行病和相关的代谢后果。虽然许多文献已经涵盖了最终形成脂肪细胞的转录事件，但较少关注指导这一过程的受体介导的细胞外信号。这篇综述将强调GPCR及其下游信使作为控制脂肪细胞分化的重要参与者。
G-protein coupled receptors (GPCRs) are a large family of proteins that coordinate extracellular signals to produce physiologic outcomes. Adenosine receptors (AR) are one class of GPCRs that have been shown to regulate functions as diverse as inflammation, blood flow, and cellular differentiation. Adenosine signals through four GPCRs that either inhibit (A1AR and A3AR) or activate (A2aAR and A2bAR) adenylyl cyclase. This review will focus on the role of GPCRs, and in particular, adenosine receptors, in adipogenesis. Preadipocytes differentiate to mature adipocytes as the adipose tissue expands to compensate for the consumption of excess nutrients. These newly generated adipocytes contribute to maintaining metabolic homeostasis. Understanding the key drivers of this differentiation process can aid the development of therapeutics to combat the growing obesity epidemic and associated metabolic consequences. Although much literature has covered the transcriptional events that culminate in the formation of an adipocyte, less focus has been on receptor-mediated extracellular signals that direct this process. This review will highlight GPCRs and their downstream messengers as significant players controlling adipocyte differentiation.
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DOI：
10.1016/0167-4889(90)90244-8
发表时间：
1990-09-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BRANDES, R;ARAD, R;BARTANA, J
通讯作者：
BARTANA, J
影响因子：
4.8
作者：
Brown, AJ;Goldsworthy, SM;Dowell, SJ
通讯作者：
Dowell, SJ
DOI：
10.1073/pnas.0805621105
发表时间：
2008-09-02
影响因子：
11.1
作者：
Birsoy, Kivanc;Soukas, Alexander;Friedman, Jeffrey M.
通讯作者：
Friedman, Jeffrey M.
影响因子：
16
作者：
Barak, Y;Nelson, MC;Evans, RM
通讯作者：
Evans, RM
影响因子：
4.1
作者：
Borglum, JD;Vassaux, G;Negrel, R
通讯作者：
Negrel, R