Human T-cell gamma chain genes: organization, diversity, and rearrangement.
Human T-cell gamma chain genes: organization, diversity, and rearrangement.
复制标题
人类 T 细胞伽马链基因：组织、多样性和重排。
DOI：
10.1126/science.3079918
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Seidman,JG
中科院分区：
文献类型：
--
作者：
Quertermous,T;Murre,C;Dialynas,D;Duby,AD;Strominger,JL;Waldman,TA;Seidman,JG
为了更好地了解人类T细胞γ链基因在免疫反应中的作用，人们对其进行了表征。这些免疫球蛋白样基因在基因组中以可变、连接和恒定的片段进行编码。人类γ基因至少包括6个可变区基因、2个连接片段和2个恒定区基因。在T细胞的发育过程中，可变片段和连接片段重新组合，形成重排基因。这种重组机制产生的人γ基因的多样性比小鼠基因组产生的基因多样性大，但比其他免疫球蛋白样基因的多样性更有限。
The human T-cell γ chain genes have been characterized in an attempt to better understand their role in immune response. These immunoglobulin-like genes are encoded in the genome in variable, joining, and constant segments. The human γ genes include at least six variable region genes, two joining segments, and two constant-region genes in germline DNA. Variable and joining segments recombine during the development of T cells to form rearranged genes. The diversity of human γ genes produced by this recombinational mechanism is greater than that produced by the murine genome but is more limited than that of other immunoglobulin-like genes.