The global burden of liver disease: the major impact of China.
The global burden of liver disease: the major impact of China.
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DOI：
10.1002/hep.27406
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Wang HY
中科院分区：
文献类型：
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作者：
Wang FS;Fan JG;Zhang Z;Gao B;Wang HY
肝病是全球疾病和死亡的主要原因。仅在中国，肝病（主要是病毒性肝炎（以乙型肝炎病毒，HBV为主）、非酒精性脂肪性肝病和酒精性肝病）影响约3亿人。1992年扩大免疫规划的实施使新感染HBV的患者数量大幅下降；然而，酒精性和非酒精性脂肪性肝病患者的数量正以惊人的速度上升。肝癌是最致命的癌症之一，是中国第二常见的癌症。中国每年约有38.3万人死于肝癌，占全球肝癌死亡人数的51%。在过去10年中，中国投入大量资金用于肝病研究、疫苗和药物开发，并招募了许多在西方接受过培训的肝病学家和科学家，为摆脱“肝病大国”的称号做出了一些重大努力。在过去20年中，中国的肝病学家和科学家在肝病预防、诊断、管理和治疗方面取得了显著进步。他们在肝病研究方面非常活跃，这从肝病学相关出版物数量的大幅增加就可以看出。然而，仍有许多挑战必须共同应对。在这篇综述中，我们讨论了中国肝病的流行病学、特征以及与肝脏相关的研究。
Liver disease is a major cause of illness and death worldwide. In China alone, liver diseases, primarily viral hepatitis (predominantly hepatitis B virus, HBV), nonalcoholic fatty liver disease and alcoholic liver disease affect approximately 300 million people. The establishment of the Expanded Program on Immunization in 1992 has resulted in a substantial decline in the number of newly HBV-infected patients; however, the number of patients with alcoholic and nonalcoholic fatty liver diseases is rising at an alarming rate. Liver cancer, one of the most deadly cancers, is the second most common cancer in China. Approximately 383,000 people die from liver cancer every year in China, which accounts for 51% of the deaths from liver cancer worldwide. Over the past 10 years, China has made some significant efforts to shed its “leader in liver diseases” title by investing large amounts of money in funding research, vaccines and drug development for liver diseases, and by recruiting many Western-trained hepatologists and scientists. Over the last two decades, hepatologists and scientists in China have made significant improvements in liver disease prevention, diagnosis, management and therapy. They have been very active in liver disease research, as shown by the dramatic increase in the number of publications in Hepatology. Nevertheless, many challenges remain that must be tackled collaboratively. In this review, we discuss the epidemiology and characteristics of liver diseases and liver-related research in China.