Self-rated health is related to levels of circulating cytokines
Self-rated health is related to levels of circulating cytokines
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DOI：
10.1097/01.psy.0000130491.95823.94
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发表时间：
2004-07-01
影响因子：
3.3
通讯作者：
Unden, AL
中科院分区：
文献类型：
--
作者：
Lekander, M;Elofsson, S;Unden, AL
目的：自我评价健康状况是长期健康的强大而独立的预测指标，但其生物学基础尚不清楚。由于与自评健康状况不佳相关的因素（例如疼痛、日常不适、精力不足和健康状况不佳）类似于普遍细胞因子引起的疾病反应的症状，因此我们研究了循环细胞因子与自评健康之间的关系。方法：在 265 名连续的初级卫生保健患者（174 名女性和 91 名男性）中，我们检查了自评和医生评价的健康状况、白细胞介素 (IL)-1β、IL-1 受体拮抗剂 (IL-1ra)、IL-6 和肿瘤坏死因子 (TNF)-α 的循环水平，这些水平是使用高灵敏度酶联法从血浆样本中测定的。 免疫测定。结果：女性自评健康状况与 IL-1beta (r = 0.27;p < .001)、IL-1ra (r = 0.19;p < .05) 和 TNF-alpha (r = 0.46;p < .001) 水平相关，但与男性无关。因此，较差的主观健康状况与较高水平的炎症细胞因子相关。即使在多元回归分析中控制了年龄、教育程度、身体健康状况和诊断，自我评价的健康状况也是比医生评价的健康状况更独立且更可靠的细胞因子水平预测因子。结论：目前的研究结果表明，个人的健康认知可能与循环细胞因子有关。由于流行病学研究表明，自评健康可以预测发病率和死亡率，因此需要了解自评健康的生物学相关性和机制。
Objective: Self-rated health is a powerful and independent predictor of long-term health, but its biological basis is unknown. Because factors associated with poor self-rated health (eg, pain, daily discomforts, and low energy and fitness) resemble symptoms of a generalized cytokine-induced sickness response, we examined the relationship between circulating cytokines and self-rated health. Methods: In 265 consecutive primary health care patients (174 women and 91 men), we examined self-rated and physician-rated health, circulating levels of interleukin (IL)-1beta, IL-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF)-alpha as determined from plasma samples using high-sensitivity enzyme-linked immunoassay. Results: Self-rated health correlated with levels of IL-1beta (r = 0.27;p < .001), IL-1ra (r = 0.19; p < .05) and TNF-alpha (r = 0.46; p < .001) in women but not in men. Thus, poorer subjective health was associated with higher levels of inflammatory cytokines. Even when controlling for age, education, physical health, and diagnoses in multiple regression analyses, self-rated health was an independent and more robust predictor of cytokine levels than physician-rated health. Conclusions: The present findings suggest that an individual's health perception may be coupled to circulating cytokines. Because epidemiological research established that self-rated health predicts morbidity and mortality, the biological correlates and mechanisms of self-rated health need to be understood.