Hexaminolevulinate Fluorescence Cystoscopy and Transurethral Resection of the Bladder in Noninvasive Bladder Tumors
Hexaminolevulinate Fluorescence Cystoscopy and Transurethral Resection of the Bladder in Noninvasive Bladder Tumors
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DOI：
10.1089/end.2008.0574
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发表时间：
2009-06-01
影响因子：
2.7
通讯作者：
Geavlete, Petrisor
中科院分区：
文献类型：
--
作者：
Geavlete, Bogdan;Multescu, Razvan;Geavlete, Petrisor
目的：比较六氨基酮戊酸（HAL）蓝光膀胱镜（BLC）和标准白色光膀胱镜（WLC）对非侵袭性膀胱肿瘤（NIBT）的诊断价值，并分析蓝光经尿道膀胱电切术（BL-TURB）的疗效。BL-TURB应用于仅通过BLC检测到的病变。确诊为NIBT的患者在18周后通过WLC和BLC进行随访。对照组包括相同数量的连续NIBT患者，仅由WLC诊断和WL-TURB治疗。结果：WLC诊断正确率为66.4%，假阳性率为9.7%，而BLC诊断正确率为95.7%，但假阳性率为13.5%。研究组复发率为5.3%，对照组复发率为23.2%。结论：HAL荧光膀胱镜检查是一种有价值的诊断方法，其准确性大大提高。BL-TURB代表了一种上级治疗方式，对复发率有显著影响。
Purpose: We compared hexaminolevulinate (HAL) blue light cystoscopy (BLC) with standard white light cystoscopy (WLC) in the diagnosis of noninvasive bladder tumors (NIBT) and analyzed the efficiency of blue light transurethral resection of the bladder (BL-TURB).Materials and Methods: WLC and BLC were performed in 64 cases. BL-TURB was applied for lesions that were detected only by BLC. Patients who received a diagnosis of NIBT were followed up after 18 weeks by WLC and BLC. The control group included the same number of consecutive patients with NIBT, diagnosed only by WLC and treated by WL-TURB.Results: WLC correctly diagnosed 66.4%, with a 9.7% rate of false-positive results, while BLC diagnosed 95.7%, but had a 13.5% rate of false-positive results. The study group had a recurrence rate of 5.3% vs 23.2% in the control group.Conclusions: HAL fluorescence cystoscopy is a valuable diagnostic method, with considerably improved accuracy. BL-TURB represents a superior treatment modality, with significant impact on the recurrence rate.